摘要
目的观察探讨瑞舒伐他汀强化治疗外周动脉粥样硬化的临床效果。方法选择本院2013年6月—2015年1月收治的外周动脉粥样硬化患者100例作为研究对象,随机分为对照组和观察组各50例。对照组患者应用瑞舒伐他汀常规剂量治疗,10 mg/次,1次/d;观察组应用瑞舒伐他汀强化剂量治疗,20 mg/次,1次/d。连续用药半年,对比两组患者血脂(总胆固醇、三酰甘油、低密度胆固醇、高密度胆固醇)水平,并观察外周动脉粥样硬化斑块(斑块大小和斑块厚度、中膜厚度)水平差异。计量资料采用t检验,P<0.05为差异有统计学意义。结果治疗后,观察组患者总胆固醇、三酰甘油、低密度胆固醇水平分别为(4.16±1.34)、(1.56±0.42)、(1.82±0.63)mmol/L,均明显低于对照组的(5.56±1.24)、(1.94±0.62)、(3.73±1.01)mmol/L,观察组高密度胆固醇水平为(2.03±0.45)mmol/L,明显高于对照组的(1.63±0.36)mmol/L,差异均有统计学意义(均P<0.05)。治疗后,观察组斑块大小、斑块厚度、中膜厚度分别为(1.21±0.30)cm2、(0.056±0.011)、(1.74±0.21)mm,均优于对照组的(1.45±0.51)cm2、(0.076±0.012)、(1.89±0.29)mm,差异均有统计学意义(均P<0.05)。结论瑞舒伐他汀治疗外周动脉粥样硬化临床效果显著,强化治疗剂量较常规剂量效果更佳,对血脂水平和斑块情况改善更显著,可进一步推广应用。
Objective To observe the clinical effect of peripheral artery atherosclerosis by intensive therapy.Methods 100 cases of peripheral atherosclerosis from June 2013 to January 2015 were selected as research subjects.The patients were randomly divided into control group and observation group,50 cases in each group.Patients in the control group were treated with the conventional therapy,10 mg/time,1 time/d,and the patients in observation group were treated with the intensive dose,20 mg/ time,1time/d.Continuous medication for half a year,compared two groups of patients with blood lipids（total cholesterol,triglyceride,low den-sity lipoprotein cholesterol,high density cholesterol） levels and observe differences in the level of peripheral atherosclerotic plaque（patch size and patch thickness and film thickness）.Measurement data using t test,P〈0.05 was considered statistically significant.Results After treatment,the total cholesterol,triglyceride,low density cholesterol levels of observation group were（4.16±1.34）,（1.56±0.42）,（1.82±0.63）mmol/L,significantly lower than those of the control group [（5.56±1.24）,（1.94±0.62）,（3.73±1.01）mmol/L],the high density cholesterol level of observation group was（2.03±0.45）mmol/L,significantly higher than the control group [（1.63±0.36）mmol/L],the differences were statistically significant（all P〈0.05）.After treatment,the plaque group size,thickness of plaque,film thickness of observation group were（1.21±0.30） cm2,（0.056±0.011）,（1.74±0.21）mm,better than those of the control group [（145±0.51） cm2,（0.076±0.012）,（1.89±0.29）mm],the differences were statistically significant（all P〈0.05）.Conclusion Rosuvastatin treatment of peripheral atherosclerosis clinical effect is remarkable,in contrast to conventional intervention dose,strengthen treatment dose effect is better,on blood lipid level and carotid plaques improved more significantly,popularization and application.
出处
《社区医学杂志》
2016年第5期4-6,共3页
Journal Of Community Medicine
