摘要
目的:探讨手足口病患儿外周血中营养素前白蛋白(PA)、纤维连接蛋白(FN)、视黄醇结合蛋白(RBP)、C-反应蛋白(CRP)、微量元素铁、锌及维生素D(VitD)水平与病情的相关性。方法:采用免疫比浊法检测PA、FN、RBP和CRP水平;采用火焰原子吸收法检测全血微量元素铁、锌水平;采用电化学发光法检测VitD水平。结果:重症组与普通组、对照组比较,PA、FN、RBP、铁、锌及VitD水平均低,CRP水平升高(P<0.05);普通组与对照组比较,PA、FN和RBP水平均降低,CRP水平升高(P<0.05);铁、锌及VitD水平在普通组和对照组间无统计学意义(P>0.05)。重症恢复期PA、FN、RBP、铁、锌及VitD水平均高于急性期(P<0.01),但仍低于对照组(P<0.05);恢复期CRP水平与对照组无统计学意义(P>0.05)。PA、FN和RBP水平与手足口病病情呈显著负相关(P<0.05);而CRP与病情呈显著正相关(P<0.05);铁、锌、VitD水平与病情呈低度负相关(P<0.05)。结论:手足口病重症病例存在营养缺乏,临床应对其进行营养状态动态评估并适量补充营养。
Objective： To detect the levels of PA,FN,RBP,CRP,Iron,Zinc,VitD in peripheral blood of children with HFMD and to explore the relationship between them and the disease. Methods： The levels of PA,FN,RBP and CRP were detected by immune turbidimetric assay; and the levels of Iron and Zinc were detected by flame atomic absorption spectrometry; while the levels of VitD were detected by electro chemilumin escence. Results： The levels of PA,FN,RBP,Iron,Zinc and VitD in the severe group were lower than those in other groups,while the levels of CRP were higher than those in other groups（ P〈0. 05）; and the levels of PA,FN and RBP in the general group were lower than that in the control group,while the levels of CRP were higher than that in the control group（ P〈0. 05）. And no significance were found of the levels of Iron,Zinc and VitD in the general group and the control group（ P〉0. 05）. The levels of PA,FN,RBP,Fe,Zn and VitD in the convalescence were higher than those in the acute phase of the severe cases（ P〈0. 01）,and lower than those in the control group（ P〈0. 05）; And no statistical significance were found of the levels of CRP between the convalescent phase of severe cases and the control group（ P〉0. 05）. There were negative correlation between the levels of PA,FN,RBP and the state of HFMD（ P〈0. 05）,while there were positive correlation between the levels of CRP and the state of HFMD（ P〈0. 05）. And there were low negative correlation between the levels of Iron,Zinc,VitD and the state of HFMD（ P〈0. 05）,respectively. Conclusion：There were nutritional deficiency in severe cases of HFMD,and the nutritional status should be assessed dynamically,then proper amount of nutrition should be supplement.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2016年第3期414-416,共3页
Chinese Journal of Immunology
