摘要
目的:观察大黄联合谷氨酰胺对脓毒血症患者胃肠功能障碍的影响。方法:选择2012年1月—2014年12月在本院重症医学科住院的脓毒血症胃肠功能障碍患者94例,随机分为研究组和对照组各47例。对照组给予MODs胃肠功能障碍治疗方法治疗,研究组在对照组的基础上给予大黄保留灌肠治疗。结果:治疗后两组的胃肠功能障碍评分、APACHEⅡ评分均明显降低,且治疗后研究组胃肠功能障碍评分、APACHEⅡ评分优于对照组(P<0.05);治疗后两组的腹腔内压、PCT均明显下降,且治疗后研究组优于对照组(P<0.05);研究组有效率为89.36%,对照组有效率为76.60%,研究组优于对照组(P<0.05);研究组MODS发生率、死亡率均低于对照组,差异均有统计学意义(P<0.05)。结论:大黄联合谷氨酰胺治疗脓毒血症患者胃肠功能障碍疗效显著,能改善患者预后。
Objective： To observe the clinical effects of Dahuang（ Radix et Rhizoma Rhei） combined with glutamine on gastrointestinal dysfunction of patients with septicopyemia. Methods： Totally 94 patients with septicopyemia hospitalized between January2012 and December 2014 were randomly divided into research group and control group,with 47 cases in each group. Control group were given MODs therapy while research group were additionally given retention enema of Dahuang（ Radix et Rhizoma Rhei）combined with glutamine. Results： The scores of gastrointestinal dysfunction and APACHEⅡdeclined obviously in both groups.Scores of gastrointestinal dysfunction and APACHEⅡin research group were better than these in control group（ P 〈 0. 05）. After the treatment,the internal pressure and PCT got apparent decrease and research group were better than control group（ P 〈 0. 05）.The effective rate was 89. 36% in research group and 76. 60% in control group; research group were better than control group（ P 〈 0. 05）. The occurrence rates of MODS and mortality in research group were lower than those in control group; the difference had statistical significance（ P 〈 0. 05）. Conclusion： Dahuang（ Radix et Rhizoma Rhei） combined with glutamine has remarkable therapeutic effects on gastrointestinal dysfunction of patients with septicopyemia,and it can improve the prognosis of the patients.
出处
《河南中医》
2016年第3期504-506,共3页
Henan Traditional Chinese Medicine
基金
陕西省教育厅基金(编号:05JK184)
陕西省中医管理局基金(编号:2007029)
关键词
脓毒血症
胃肠功能障碍
大黄
谷氨酰胺
septicopyemia
gastrointestinal dysfunction
Dahuang（Radix et Rhizoma Rhei）
glutamine
