摘要
目的系统评价Survivin蛋白表达与中国人群前列腺癌及其不同临床病理特征的相关性。方法计算机检索PubMed、EMbase、CBM、CNKI、VIP和WanFang Data数据库,搜集关于Survivin蛋白表达与中国人群前列腺癌及其不同临床病理特征相关性的病例-对照研究,检索时限均为从建库至2015年11月。由2位评价者独立进行文献筛选、资料提取和偏倚风险评价,然后采用RevMan 5.3软件进行Meta分析。结果最终纳入32个病例-对照研究,其中前列腺癌患者1 613例,前列腺增生患者708例,正常前列腺对照93例。Meta分析结果显示:前列腺癌患者Survivin蛋白的表达量高于前列腺增生患者[OR=32.95,95%CI(19.88,54.63),P<0.000 01]和正常前列腺对照组[OR=75.78,95%CI(26.97,212.98),P<0.000 01],差异均有统计学意义;前列腺癌中低分化组Survivin蛋白的表达量高于高分化组[OR=4.45,95%CI(3.13,6.32),P<0.000 01],前列腺癌J-W-P分期C+D期组Survivin蛋白的表达量高于A+B期组[OR=5.42,95%CI(2.91,10.10),P<0.000 01],前列腺癌伴淋巴结转移组Survivin蛋白的表达量高于不伴淋巴结转移组[OR=4.07,95%CI(2.91,10.10),P<0.000 01],差异均有统计学意义。结论 Survivin蛋白表达与中国人群前列腺癌及其临床病理特征有显著相关性。受纳入研究样本量和质量限制,上述结论需进一步开展高质量研究加以验证。
Objective To systematically review the correlation between Survivin expression and prostate cancer, as well as its clinicopathologic features in Chinese population. Methods Such databases as Pub Med, EMbase, CBM, CNKI, VIP and Wan Fang Data were electronically searched from inception to November, 2015 to collect case-control studies about the correlation between Survivin expression and prostate cancer, as well as its clinically pathologic characteristics in Chinese population. Two reviewers independently screened literature, extracted data and assessed the methodological quality of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results A total of 32 casecontrol studies were included, involving 1 613 prostate cancer cases, 708 benign prostatic hyperplasia cases, and 93 controls. The results of meta-analysis showed that the prostate cancer group had a higher Survivin expression level when compared with the benign prostatic hyperplasia group(OR=32.95, 95% CI 19.88 to 54.63, P〈0.000 01) or the control group(OR=75.78, 95% CI 26.97 to 212.98, P〈0.000 01). Moreover, the expression level of Survivin was higher in the low and medium differentiation group than in the high differentiation group(OR=4.45, 95% CI 3.13 to 6.32, P〈0.000 01), higher in the stage of C+D than in the stage of A+B(OR 5.42, 95% CI 2.91 to10.10, P〈0.000 01), and higher in the prostate cancer with lymph node metastasis than in the prostate cancer without lymph node metastasis(OR 4.07, 95% CI 2.91 to 10.10, P〈0.000 01). Conclusion Current evidence indicates that the expression level of Survivin is significantly correlated with prostate cancer and its clinicopathologic features in Chinese population. Due to the limited quantity and quality of included studies, above conclusions need to be verified by conducting more high quality studies.
出处
《中国循证医学杂志》
CSCD
2016年第3期270-277,共8页
Chinese Journal of Evidence-based Medicine