摘要
目的:分析心悸怔忡古方数据库的构建及组方配伍规律。方法:对《中医方剂大辞典》《中华医典》中有关治疗心悸怔忡的方剂进行收集整理,并将所得信息进行标准化处理,建立心悸怔忡古方数据库,应用频数统计及关联规则的方法对查询出的常用药物、药对和组方进行规律分析。结果:(1)对于心悸怔忡古方朝代进行分析,发现宋、明、清用的心悸怔忡古方较多,分别占36.93%、23.55%和22.36%,而唐、元及东汉的心悸怔忡古方较少,均不超过10%。其中,宋、明、清的总和占82.84%,说明心悸怔忡古方在宋明清时代有较大的发展;(2)在收集的501首方剂中,以补气药的出现频数最高,其次为养心安神药、补血药、重镇安神药等。远志、人参为方中出现频数最高的药对组合,出现频数排在前10位的单味药依次为人参、甘草、远志、茯神、茯苓、当归、麦冬、朱砂、酸枣仁、地黄;(3)常用药对涉及20多对配伍,其中主要以人参、远志、茯神、甘草几味为配伍核心;在出现支持度大于80的药对中,大多是以人参为中心的配对;(4)心悸怔忡古方中比较常见的三味药连用药团,其中支持度在44以上的20组药团中,以人参+远志为核心的药团有7组,人参+甘草为核心的药团有4组,以人参+茯神为核心的药团有3组;(5)通过频繁项集以及关联规则分析后,可以得出药物之间的相互依赖关系,心悸怔忡古方的重点用药主要为人参、远志、茯苓、麦冬、当归、茯神、甘草、酸枣仁。结论:《中医方剂大辞典》《中华医典》中治疗心悸怔忡的方剂用药精当,内外兼顾,标本兼治,能够为临床辨证论治心悸怔忡提供一定参考依据。
Objective： To discuss the construction of ancient palpitation prescriptions database and to analyze the compatibility law of the prescriptions. Methods： prescriptions relating to the treatment of palpitation were collected from Chinese Prescriptions Dictionary and Chinese Medical Classics. The standardized information is used to establish an ancient palpitation database. By the application of frequency statistics and association rules method,the frequently used drugs,drug pairs and the law of the prescription were analyzed. Results： 1 It is found that most of the ancient palpitation prescriptions were created in Song dynasty,Ming dynasty and Qing dynasty. 2 in the collection of 501 prescriptions,the most frequently used drugs are those can tonify human Qi3 More than20 compatibility pairs are found the most commonly used drugs,with ginseng herb being the most popular medicine. 4The combination of ginseng and Yuanzhi（ Polygala tenuifolia） is the most popularly used one in drug groups. 5 The inter-dependent drugs in palpitation medication are mainlys ginseng,Polygala,Poria,etc. Conclusion： In treatment of palpitation,the ancient prescriptionsin book named Chinese Prescriptions Dictionary and Chinese Medical Classics can provide valuable references for present clinical practices.
出处
《中医学报》
CAS
2016年第1期105-108,共4页
Acta Chinese Medicine
基金
国家973计划课题(2012CB518401)
关键词
心悸
怔忡
古方数据库
配伍规律
palpitations
ancient prescriptions
database
compatibility law
