摘要
放射性肠炎是在腹腔、腹膜后、盆腔后恶性肿瘤患者接受放疗,所引起的累及到小肠、结肠、直肠等肠道并发症状。中医学认为,肿瘤患者正气不足,加之毒邪入侵,正虚邪盛,致脏腑、气血、津液受损,而对于已虚之体再进行放射治疗,必然导致进一步的本虚,不耐邪毒。因而呈现热毒、湿浊、瘀血、正虚的基本病机特点。中医药在辨证论治的基础上采用中药汤剂内服、中药灌肠、针灸等多途径治疗能改善临床症状、提高临床疗效,其作用机制可能与减少细胞炎性因子与自由基释放,减轻炎症反应,抗氧化损伤有关。实验研究也显示,中药具有抗炎、抗氧化、抗纤维化、促进肠黏膜修复等多层次、多靶点的作用机制。可见,中医药和中西医结合治疗形式多样,疗效显著,安全性好。同时,具有多层次、多靶点的作用机理,但多中心、高质量的临床研究较少。
The radiation enteritis is patient＇s small intestine,colon,rectum and other intestinal concurrent symptoms caused by radiotherapy on the abdominal cavity,retroperitoneal,or pelvic cancer. Chinese medicine believes that cancer patients who suffer from Qi deficiency coupled with toxin invasion which can cause organs,blood,and body fluid damage would be much weaker after radiation therapy. Based on Chinese medicine syndrome differentiation,the oral herbal decoction,enema,acupuncture and other multi-channel treatment can improve the clinical symptoms as well as drug efficacy. The mechanism may be associated with the reduced release of cell inflammatory cytokines and free radicals,the reduced inflammation,and the anti-oxidation effect. Experimental studies have proved that traditional Chinese medicine can function in anti-inflammatory,anti-oxidation,anti-fibrosis,and repairing the intestinal mucosal,working in multi-level and multi-target mechanism. Therefore,the combination therapy of TCM and western medicine in various forms can achieve significant curative effect with security.
出处
《中医学报》
CAS
2016年第1期121-124,共4页
Acta Chinese Medicine
基金
湖北省卫生厅科技项目(20110256A)
关键词
放射性肠炎
中医药疗法
中西医结合疗法
radiation enteritis
Chinese medicine therapy
Chinese and Western medicine therapy
