摘要
目的探讨二维超声（2D—US）、超声弹性成像（UE）、超声造影（CEUS）三种超声成像技术对肿瘤大小的测量误差与雌激素受体（ER）、孕激素受体（PR）、血管内皮生长因子（VEGF）表达的相关性。方法选择50例乳腺癌患者，术前分别应用2D-US、UE、CEUS及术后测量肿瘤大小，通过免疫组化法检测肿瘤ER、PR及VEGF的表达情况，并做相关性分析。结果2D-US、UE、CEUS测值与病理测值的差值分别为（-0．594±-0．34）cm、（-0．20±-0．14）cm、（-0．40±-0．31）cnl，差值两两比较，差异有统计学意义（F=20．497，P〈0．001）。UE与2D-US的测量差值≤0．44cm时比差值〉0．44cmER、PR阳性表达率高；CEUS与2D．US的测量差值≤0．19cm时比差值〉0．19cmVEGF阳性表达率低，三种超声技术对乳腺癌肿瘤大小测量存在差异，ER、PR表达阳性时，UE与2D-US测值的差异趋向越小；VEGF表达阳性时，CEUS与2D．US测值的差异趋向越大。结论乳腺癌ER、PR、VEGF表达与三种不同超声成像技术测量误差之间存在相关性，提示乳腺癌分子病理学差异对超声成像可造成影响，这有助于认识不同超声成像技术对乳腺癌测量误差的原因与规律。
Objective To explore the three ultrasonic technologies of two -dimensional ultrasound （2D - US）, ultrasonic elastography （UE） and contrast -enhanced ultrasound （CEUS） for the measurement error in breast cancer and the correlation with the expression of ER, PR,VEGF. Methods 50 patients with breast cancer were meas- ured by 2D- US ,UE, CEUS preoperatively,and the pathological specimen were measured postoperatively. Then used the immunohistochemistry to detect the expression of ER, PR, VEGF in tumor, and analyzed the correlation with the measurement errors. Results The results of differences between 2D - US, UE, CEUS and pathology were respectively as follows ： （ - 0.59 ± - 0.34） cm, （ - 0.20± - 0.14） cm, （ - 0.40 ± - 0.31 ） cm, and the differences were statistically significant（ F = 20. 497 ,P 〈 0.001 ）. The positive expression rate of ER and PR was high if the difference between UE and 2D - US was less than or equal to 0.44cm. And the positive expression rate of VEGF was low if the difference between CEUS and 2D - US was less than or equal to 0.19cm. Three ultrasonic technologies in the measurement of breast cancer were different, the trend of difference between UE and 2D - US was smaller if the ER and PR were positively expression,and the trend of difference between CEUS and 2D -US was bigger if the VEGF was positivelyexpression. Conclusion There is correlation between different immunohistochemical expression of breast cancer with measurement error in three different ultrasonic imaging technologies. The resuhs suggest that the molecular pathology difference of breast cancer can impact on ultrasonic imaging, which contributes to know the reason and regulation of measurement error in different ultrasonic imaging technology.
出处
《中国基层医药》
CAS
2016年第5期641-645,I0001,共6页
Chinese Journal of Primary Medicine and Pharmacy
基金
基金项目：广东省科技计划项目（粤财教2013-97）
关键词
超声检查
乳腺肿瘤
免疫组织化学法
测量方法
Ultrasonography
Breast neoplasms
Immunohistochemistry
Measuring method
