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不同二氧化碳气腹压对腹腔镜结直肠癌手术患者腹腔微转移的影响 被引量:8

The effect of different CO2 pneumoperitoneum pressure on micro metastasis in peritoneal laparoscopic colorectal cancer
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摘要 目的探讨不同二氧化碳气腹压对腹腔镜结直肠癌手术患者腹腔微转移的影响。方法将入组的80例结直肠癌患者随机分成A、B、C、D组,每组20例,A组腹腔镜术中CO:气腹压维持在14mmHg;B组腹腔镜术中c0。气腹压维持在12mmHg;C组腹腔镜术中c0。气腹压维持在10mmHg;D组为对照组(传统开腹手术组),采用RT—PCR方法检测不同气腹压组腹腔镜结直肠癌根治术患者术前及术后腹水与腹膜组织中CEAmRNA及CK20mRNA的表达情况,并与开腹组比较。结果进腹后四组比较,腹腔冲洗液CEAmRNA表达差异无统计学意义(x2=0.579,P=0.901),进腹后腹腔冲洗液CK20mRNA表达差异无统计学意义(x2=0.205,P:0.977);进腹后四组腹膜组织CEAmRNA表达差异无统计学意义(x2=0.640,P=0.887),进腹后腹膜组织CK20mRNA表达差异无统计学意义(x2=0.376,P=0.945);关腹前A、B、C、D四组腹腔冲洗液CEAmRNA表达差异无统计学意义(x2=0.201,P:0.978),腹腔冲洗液CK20mRNA表达差异无统计学意义(x2=0.404,P=0.939);关腹前A、B、C、D四组比较腹膜组织CEAmRNA表达差异无统计学意义(x2=0.784,P=0.853),腹膜组织CK20mRNA表达差异无统计学意义(x2=0.784,P=0.853)。结论CO2气腹压在10~14mmHg行腹腔镜结直肠癌根治术不增加患者腹腔及腹膜微转移概率,但对腹腔空间较小或肥胖患者,气腹压低易减少腹腔空间,增加腹腔镜手术难度。
出处 《中国基层医药》 CAS 2016年第5期774-777,共4页 Chinese Journal of Primary Medicine and Pharmacy
基金 基金项目:江西省科技计划项目(20122BBG70123)
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