摘要
目的:分析亚临床甲状腺功能减退症(subclinical hypothyroidism,SCH)患者血脂水平和超敏C反应蛋白(hs-CRP)水平变化情况,探析其和促甲状腺激素(TSH)水平的相关性。方法:前瞻性选取90例亚临床甲状腺功能减退症患者,根据TSH水平将其分为轻度、中度、重度3个组,每组30例,同时选取健康者30例为对照组,观察4组患者TSH、血脂指标(TC、TG、HDL-C、LDL-C、ApoA、ApoB、Lpa)及hs-CRP水平变化情况,分析血脂和hs-CRP与TSH水平相关性。结果:亚临床甲减各亚组TSH、TC、TG、Lpa、hs-CRP水平明显高于对照组(P<0.05);亚临床甲减患者HDL-C、LDL-C、ApoA、ApoB水平较对照组增高,中重度组HDL-C、LDL-C、ApoB水平明显高于对照组(P<0.05),重度组ApoA水平明显高于对照组(P<0.05);中度组LDL-C水平明显高于轻度组(P<0.05),且重度组水平明显高于中度组(P<0.05);重度组ApoB水平明显高于轻度组(P<0.05);经spearman相关性分析,TC、TG、LDL-C、ApoB、Lpa、hs-CRP和TSH水平呈明显正相关(P<0.05),HDL-C、ApoA和TSH水平无明显相关性(P<0.05)。结论:亚临床甲状腺功能减退症患者血脂和超敏C反应蛋白水平异常升高,且随着病情进展逐渐升高,和促甲状腺激素水平有密切相关。
Objective：To analyze changes of serum lipid and hs-CRP levels in patients with subclinical hypothyroidism and to explore their correlations with TSH level.Methods：A total of 90 patients with subclinical hypothyroidism were included in the study and divided into the mild,moderate,and severe groups according to TSH level with 30 cases in each group;meanwhile,30 healthy individualswere served as the control groups.The changes of the levels of TSH,serum lipid indicators（TC,TG,HDL-C,LDL-C,ApoA,ApoB,and Lpa）,and hs-CRP in the four groups were observed.The correlation of serum lipid and hs-CRP with TSH was analyzed.Results：The levels of TSH,TC,TG,Lpa,and hs-CRP in the subclinical hypothyroidism subgroups were significantly higher than those in the control group（P〈0.05）.The levels of HDL-C,LDL-C,ApoA,and ApoB in patients with subclinical hypothyroidism were increased when compared with the control group.The levels of HDL-C,LDL-C,and ApoB in the moderate and severe groups were significantly higher than those in the control group（P〈0.05）.ApoA level in the severe group was significantly higher than that in the control group（P〈0.05）.LDL-C in the moderate group was significantly higher than that in the mild group（P〈0.05）,and that in the severe group was significantly higher than that in the moderate group（P〈0.05）.ApoB level in the severe group was significantly higher than that in the mild group（P〈0.05）.Spearman correlation analysis showed that TC,TG,LDL-C,ApoB,Lpa,and hs-CRP were positively correlated with TSH level（P〈0.05）,while HDL-C and ApoA had no correlation with TSH level（P〈0.05）.Conclusions：The levels of serum lipid and hs-CRP are abnormally elevated in patients with subclinical hypothyroidism,and are gradually increased along with the disease progression,which is closely associated with TSH level.
出处
《海南医学院学报》
CAS
2016年第9期869-871,875,共4页
Journal of Hainan Medical University
基金
汕府科技项目([2014]62)~~
