摘要
目的:比较四君子汤加减联合化疗和单独使用化疗对结直肠癌患者在临床疗效、生活质量以及化疗不良反应方面的影响。方法:检索自建库到2015年10月比较四君子汤加减联合化疗方案和单独使用化疗对结直肠癌临床疗效、生活质量以及化疗不良反应的随机对照研究的中英文文献。应用Rev Man 5.3软件评价纳入文献质量,并进行统计分析。结果:经严格筛选,最终纳入8篇随机对照文献,涉及483例患者,其中四君子汤加减联合化疗组245例,单独使用化疗组238例。Meta分析结果显示:在生活质量、化疗不良反应方面,两组结果差异有显著的统计学意义(P<0.000 01),在临床疗效方面,两组差异无统计学意义(P=0.19)。结论:四君子汤加减不仅可以降低结直肠癌患者的化疗不良反应发生率,而且可以改善其生活质量。
Objective： To compare the chemotherapy combined with Sijunzi Tang and chemotherapy alone in clinical efficacy,quality of life,and side effects in treatment of colorectal cancer. Method： We searched for the literature of randomized controlled trials,published before October 2015 in both Chinese and English,comparing the chemotherapy combined with Sijunzi Tang and chemotherapy alone in clinical efficacy,quality of life,and side effects in treatment of colorectal cancer. Software Review Manager 5. 3 was used to evaluate the quality of the included literature and conduct statistics work. Result： After strict screening,the 8 literature of randomized controlled trials were selected finally, involving 483 patients, the 245 cases with chemotherapy combined with Sijunzi Tang and 238 cases with chemotherapy alone. Results of Meta-analysis showed that there were statistically significant differences between two group in the quality of life and side effects（ P〈 0. 000 01）.There was no significant difference in clinical efficacy（ P = 0. 19）. Conclusion： Sijunzi Tang can not only decrease the incidence of side effects of chemotherapy in patients with colorectal cancer,but also improve the quality of life for the patients.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第6期204-209,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81473565)
江苏省"十二五"中医药重点学科基金项目(JS1301)
江苏省中医消化病临床医学研究中心项目(BL2014100)
江苏省中医院院级项目(Y14059)
