摘要
目的探讨静脉注射丙种球蛋白(IVIG)对川崎病患儿炎症反应及氧化应激反应的影响。方法选取90例川崎病的患儿,随机分为A组、B组、C组,每组30例。A组静脉注射IVIG 1g/(kg·d),B组IVIG 2 g/(kg·d),C组IVIG3 g/(kg·d)。比较3组的症状缓解情况、炎症反应、氧化应激、冠脉损伤及不良反应。结果 B组和C组的临床症状的消退时间、住院时间均显著短于A组(P<0.05),TNF-α、IL-6、IL-10、MDA均显著低于A组(P<0.05),SOD、GSH-Px显著高于A组(P<0.05)。A组冠脉损伤的发生率显著高于B组和C组(P<0.05)。结论 IVIG 2 g/(kg·d)剂量能显著缓解川崎病患儿的炎症反应和氧化应激损伤,减少冠脉损伤。
Objective To explore the effect of intravenous immunoglobulin（ IVIG） on inflammatory reaction and oxidative stress reaction of children with Kawasaki disease. Methods A total of 90 children with Kawasaki disease were randomly divided into group A（ treated with IVIG1 g / kgper day）,group B（ treated with IVIG 2 g / kg per day） and group C（ treated with IVIG 3 g / kg per day）. Remission of symptoms,inflammatory reaction,oxidative stress,coronary injury and adverse reaction were compared among three groups. Results The remission time of clinical symptoms and hospital stay in the group B and C were significantly shorter than those in the group A（ P〈0. 05）,the levels of TNF-α,IL-6,IL-10 and MDA were significantly lower than those in the group A（ P〈0. 05）,and the SOD and GSH-Px levels were significantly higher than those in the group A（ P〈0. 05）. The incidence rate of coronary artery injury in the group A was significantly higher than that in the group B and C（ P〈0. 05）. Conclusion The 2 g /（ kg·d） IVIG can significantly relieve the inflammatory reaction and oxidative stress injury in children with Kawasaki disease,and reduce the coronary injury.
出处
《实用临床医药杂志》
CAS
2016年第5期103-106,共4页
Journal of Clinical Medicine in Practice
关键词
静脉注射
丙种球蛋白
川崎病
炎症反应
氧化应激
intravenous injection
intravenous immunoglobulin
Kawasaki disease
inflammatory reaction
oxidative stress
