摘要
目的：制定福建省某三级甲等医院骨科抗菌药物使用强度,以期为某院骨科抗菌药物的合理应用和科学管理提供参考依据。方法：借助Medline、Embase、PubMed、The Cochrane Library、CNKI、VIP、WanFang Data数据库,检索抗菌药物相关的指南、专家共识、随机对照试验或Meta分析、抗菌药物法规文件,结合某院骨科疾病分布特点,制定某院骨科抗菌药物临床应用规范,以此为理论依据,制定某院骨科抗菌药物使用强度的理论值,并结合患者的病理生理特点、临床表现、检验检查指标等具体情况,对理论值进行校正,最终制定某院骨科抗菌药物使用强度。结果：按照证据等级最终纳入研究24篇,骨科抗菌药物使用强度的实际值与理论值分别为每百人天85.43 DDDs、每百人天11.03～31.17 DDDs,经校正后某院骨科抗菌药物使用强度为每百人天30.45 DDDs,与实际值比较,具有统计学差异（Z=-2.137,P〈0.001）。结论：某院骨科抗菌药物的临床应用存在诸多不合理之处,需从医院、临床医生、药学部门三个层面制定合理的抗菌药物管理策略,进一步提高某院抗菌药物临床应用的合理化水平。
OBJECTIVE To establish antibiotic usage intensity to provide a basis of rational use and scientific management of antibiotics in orthopedics.METHODS Orthopedic disease guidelines,expert consensus,randomized controlled trials and meta analyses were retrieved through Medline,Embase,PubMed,The Cochrane Library,CNKI,VIP,WanFang Data database,to formulate antibiotic clinical specifications in orthopedics,and set theoretical value of antibiotic intensity.Pathological and physiological characteristics,clinical manifestations,inspection and examination parameters of patients were combined to calibrate theoretic values,and finally establish antibiotic intensity in orthopedics.RESULTS According to the level of evidence,24 articles were collected.Actual value and theoretical value of antibiotic usage intensity were 100 person day 85.43 DDDs and 100 person day 11.03～31.17 DDDs,respectively.The correct value was 100 person day 30.45 DDDs（Z=-2.137,P〈0.001）.CONCLUSION There are many unreasonable elements of antibiotics utilization in orthopedics,and the rational antibiotic management strategy must be made from three levels（including hospital,doctor and pharmacy department）,which will help to improve clinically rational application of antibiotics.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2016年第6期492-498,共7页
Chinese Journal of Hospital Pharmacy
基金
福建省自然科学基金(编号:2013J01382)
关键词
抗菌药物
抗菌药物使用强度
骨科
antibiotics
antibiotic usage intensity
orthopedics
