摘要
目的了解寻常型银屑病病人外周血中白细胞介素36(IL-36)水平及其与银屑病关系,探讨其在银屑病发病机制中作用。方法应用酶联免疫吸附试验(ELISA)法,对45例寻常型银屑病病人(进展期27例,静止期18例)及40例健康对照者外周血IL-36水平进行检测,分析其与银屑病皮损面积与严重度指数(PASI)评分的关系。结果寻常型银屑病病人血清IL-36水平高于健康对照组(t=9.6,P<0.01),进展期高于静止期(t=9.4,P<0.01);寻常型银屑病病人血清IL-36水平与其PASI评分呈显著正相关(r=0.73,P<0.01)。结论 IL-36可能在银屑病发病过程中发挥重要作用,并与疾病的严重程度呈正相关。
Objective To investigate the levels of Interleukin 36 （IL-36） in peripheral blood of patients with psoriasis vulgaris （PV） and its association with the disease. Methods Employing enzyme linked immunosorbent assay （ELISA）, the le- vels of IL-36 in peripheral blood of 45 PV patients-27 with active stage, and 18 with resting phase-and 40 healthy individuals were detected, the results were compared with skin-lesion area and PASI score. Results Serum IL-36 levels were higher in PV pa- tients than that in the healthy controls （t 9.6,P〈0.01）, that in active stage were higher than that in the resting phase （t 9.4, P〈0.01）. Serum IL-36 levels in the patients were positively correlated with PASI score （r=0.73,P〈0.01）. Conclusion Se- rum IL36 is likely to play an important role in development of psoriasis vulgaris and show a positive correlation with the extent of severity of the disease.
出处
《青岛大学医学院学报》
CAS
2016年第1期49-50,53,共3页
Acta Academiae Medicinae Qingdao Universitatis
