摘要
溃疡性结肠炎(ulcerative colitis,UC)目前尚无有效的根治手段,但多数患者可通过药物治疗使病情得到有效控制.目前,氨基水杨酸类制剂仍是UC治疗的中流砥柱;糖皮质激素抗炎作用强,诱导缓解速度快,但考虑到其不良反应及激素依赖或抵抗等问题,临床应用要严格掌握其适应症及使用方法;生物制剂对UC患者,尤其是难治性UC患者显示出较大的潜力.近年来,UC治疗的新型药物及传统药物的新剂型相继面世,治疗方案亦是不断推陈出新,尤其是与以往传统"升阶梯"治疗方案截然相反的"降阶梯"方案的提出,更是为UC的治疗提供了新思路.本文旨在对UC治疗的新进展进行系统总结.
Ulcerative colitis （UC） still lacks the cure, but most patients can be well managed with drug therapy. Aminosalicylates remain the mainstay treatment for UC patients. Glucocorticoids have remarkable anti-inflammatory effects and can induce remission rapidly. However, many cases may develop dependency or resistance, and adverse events during long-term use may also occur. As a result, glucocorticoids should be prescribed strictly according to the indication and application methods. Biologicals have great potentials for UC patients, especially for refractory UC patients. Nowadays, more and more new drugs and new formulations of traditional drugs, as well as novel regimens are introduced. The top-down therapy, which is utterly contradictory to the conventional step-up strategy, revolutionizes UC treatment. This paper aims to provide a comprehensive, evidence- based summary of current therapies for UC.
出处
《世界华人消化杂志》
CAS
2016年第7期1054-1063,共10页
World Chinese Journal of Digestology
