摘要
目的研究杭州地区不同孕期女性甲状腺激素水平变化特点,了解甲状腺功能减低症的发病情况。方法选取无相关甲状腺病史的妊娠女性165例,非妊娠健康女性181例,采用化学发光免疫分析法检测血清中的三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺激素(TSH)水平。结果孕早期、孕中期、孕晚期各组与对照组间激素水平(FT3、FT4)比较差异有统计学意义(P<0.05);TT3、TT4激素水平与对照组比较差异无统计学意义(P>0.05)。早孕期组、中孕期组与晚孕期组、对照组间的TSH水平比较差异均有统计学意义(P<0.05)。中孕、晚孕期组的临床甲状腺功能减低症患病率较早孕期组比较差异有统计学意义(P<0.05);亚临床甲状腺功能减低症患病率各孕期组比较,差异无统计学意义(P>0.05)。结论妊娠期女性甲状腺激素水平随孕期不同发生相应改变,检测甲状腺激素水平对筛查和干预甲状腺功能减低症具有重要的优生学价值。
Objective To investigate the changes and features of thyroid hormones in pregnant women of different gestation,so as to understand the incidence of hypothyroidism. Methods 165 pregnant women without thyroid related medical history and181 healthy nonpregnant women were selected for the study,and Thetriiodothyronine（ TT3）,thyroxine（ TT4）,free triiodothyronire（ FT3）,free thyroxine（ FT4） and thyroidstimulatinghormore（ TSH） levels were measured by chemiluminescent method. Results The differences of thyroid related hormone（ FT3,FT4） levels among early- gestation,min- gestation,late- gestation women and women in the control group were statistically significant（ P〈0. 05）. The difference on the levels of TT3 and TT4between the three groups and the control group was not statistically significant（ P〉0. 05）. The differences of TSH hormone levels among early- gestation,min- gestation,late- gestation women and women in the control group were statistically significant（ P〈0. 05）. The incidence rate of clinical hypothyroidism in min- gestation and late- gestation groups were obviously higher than that of early- gestation,and all these differences were statistically significant（ P〈0. 05）. But the differences of incidence rate of sub- clinical hypothyroidism among each stages of gestation were not statistically significant（ P〉0. 05）. Conclusion Thyroidhormones of pregnant women changes in different gestation periods. Detection of gestational thyroid hormone levels plays an important eugenic value in the screening and intervention of hypothyroidism.
出处
《中国卫生检验杂志》
CAS
2016年第6期838-840,共3页
Chinese Journal of Health Laboratory Technology
