摘要
1例82岁女性患者,既往合并多种基础疾病,因肺部感染入院。患者曾多次痰培养检出鲍曼不动杆菌,给予替加环素(100 mg,q 12 h,ivgtt)抗感染治疗。替加环素用药8 d后,患者出现血小板降低,考虑为药源性血小板减少,于用药11 d后停用兰索拉唑、低分子肝素钙等可能引起血小板减少的药物,并继续应用替加环素抗感染治疗。患者肺部感染控制稳定,但血小板持续减少至42×109·L-1,考虑替加环素与血小板减少很可能相关,于用药19 d后停用。停用替加环素5 d后患者血小板逐渐恢复至102×109·L-1,于入院治疗33 d后出院。
One 82-year-old female patient combined with a variety of basic diseases was hospitalized because of pulmonaryinfection. Several results of sputum culture confirmed Acinetobacter baumannii infection and tigecycline （100 mg, q 12 h, ivgtt） wasadministered for anti-infective therapy. Eight days later, the patient appeared drug-induced thrombocytopenia. About 11 days aftertigecycline therapy, lansoprazole and low-molecular-weight heparins calcium which may cause thrombocytopenia were discontinued.About 19 days after tigecycline therapy, the patient＇s pulmonary infection was in stable condition but her platelets declined to 42 ×109·L-1, tigecycline was discontinued due to the thrombocytopenia. Five days later, the patient＇s platelets gradually returned to 102 ×109·L-1, and the patient was discharged after 33 days＇ hospitalization.
出处
《中国药物应用与监测》
CAS
2016年第2期125-127,共3页
Chinese Journal of Drug Application and Monitoring
关键词
替加环素
肺部感染
血小板降低
药品不良反应
Tigecycline
Pulmonary infection
Thrombocytopenia
Adverse drug reaction
