摘要
目的探讨百令胶囊对狼疮性肾炎(lupus nephritis,LN)患者白介素-2(interleukin-2,IL-2)、补体及感染率的影响。方法将120例LN患者随机分成观察组和对照组,每组60例。2组常规治疗相同,观察组给予百令胶囊(每次1 g,每天3次)治疗,比较2组治疗12个月临床疗效、感染率、IL-2、补体C3及药物不良反应情况。结果治疗12个月,与对照组相比,观察组IL-2、补体C3和血白蛋白显著升高,尿蛋白、尿红细胞和SLEDAI显著降低,差异均有统计学意义(P<0.05)。观察组有效率(88.33%)显著高于对照组(71.67%),感染率(21.67%)显著低于对照组(45.00%),差异均有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义。结论百令胶囊通过调节IL-2和补体C3水平提高LN的临床疗效,降低感染率,且不增加药物不良反应。
OBJECTIVE To explore the effect of Bailing Capsules on interleukin-2（IL-2）, complement and infection rate in patients with lupus nephritis. METHODS All of 120 patients with lupus nephritis were randomly divided into the observe group（n=60）and the control group（n=60）. Patients in 2 groups all accepted the conventional treatment, while the patients in the observed group were given the treatment of Bailing Capsules（1g tid）. The difference of clinical curative effect, infection rate, IL-2, complement 3（C3） and adverse drug reaction were compared between the 2 groups after 12 months. RESULTS After 12 months, compared with the control group, in the observe group, the concentrations of IL-2, C3 and serum albumin were significantly higher（P〈0.05）, and the concentration of urine protein, urine red blood cells and SLEDAI were significantly lower. The effective rate in the observe group（88.33%） was significantly higher than that in the control group（71.67%）（P〈0.05）. The infection rate during the 12 months follow up in the observe group（21.67%） was significantly lower than that in the control group（45.00%）（P〈0.05）. There was no significant difference of adverse drug reactions in the observe group（38.33%）and in the control group（36.67%）. CONCLUSION Bailing Capsules could improve clinical curative effect and reduce the infection rate by adjusting the level of IL-2 and C3, and didn＇t increase in adverse drug reactions.
出处
《中国现代应用药学》
CAS
CSCD
2016年第3期364-368,共5页
Chinese Journal of Modern Applied Pharmacy
关键词
百令胶囊
狼疮性肾炎
感染
白介素-2
补体
Bailing Capsules
lupus nephritis
infection
interleukin-2
complement
