1Liu X,Gu X,Li Z,Li X,Li H,Chang J,et al.Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy.J Am Coll Cardiol 2006; 48:1438-1447.
2Gao R,Zhang J,Cheng L,Wu X,Dong W,Yang X,et al.A phase Ⅱ,randomized,double-blind,multicenter,based on standard therapy,placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure.JAm Coll Cardiol 2010; 55:1907-1914.
4Gassmann M,Casagranda F,Orioli D,Simon H,Lai C,Klein R,et al.Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor.Nature 1995; 378:390-394.
5Lee KF,Simon H,Chen H,Bates B,Hung MC,Hauser C.Requirement for neuregulin receptor erbB2 in neural and cardiac development.Nature 1995; 378:394-398.
6Meyer D,Birchmeier C.Multiple essential functions of neuregulin in development.Nature 1995; 378:386-390.
7Crone SA,Zhao YY,Fan L,Gu Y,Minamisawa S,Liu Y,et al.ErbB2 is essential in the prevention of dilated cardiomyopathy.Nat Med 2002; 8:459-465.
8Jones LW,Haykowsky M,Peddle CJ,Joy AA,Pituskin EN,Tkachuk LM,et al.Cardiovascular risk profile of patients with HER2/neu-positive breast cancer treated with anthracycline-taxane-containing adjuvant chemotherapy and/or trastuzumab.Cancer Epidemiol Biomarkers Prev 2007; 16:1026-1031.
9Lemmens K,Doggen K,De Keulenaer GW.Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease:implications for therapy of heart failure.Circulation 2007; 116:954-960.
10Stanley WC,Hoppel CL.Mitochondrial dysfunction in heart failure:potential for therapeutic interventions? Cardiovasc Res 2000; 45:805-806.