摘要
目的:考察葛根素及葛根提取物在大鼠体内的药动学特征,并比较两者药动学行为的差异。方法:24只SD大鼠随机分为葛根素(300、100 mg/kg)和葛根素提取物高、低剂量(相当于葛根素300、100 mg/kg)组,各组大鼠分别于ig给药前及给药后0.083、0.17、0.33、0.5、0.67、1、1.5、2、3、4、6、8、10 h经眼球后静脉丛采血0.2 ml测定血药浓度,采用DAS 3.0软件计算药动学参数。结果:与葛根素高剂量组比较,葛根素低剂量组大鼠AUC0-t、cmax显著增加,而CL则显著降低;且葛根素低剂量组以及葛根提取物高、低剂量组MRT0-t也显著降低(P<0.01)。葛根提取物低剂量组与葛根提取物高剂量组大鼠药动学参数差异无统计学意义(P>0.05)。结论:葛根素和葛根提取物在大鼠体内的药动学行为存在差异,葛根提取物中的某些成分可能会加快体内葛根素的清除,从而缩短其在体内的平均滞留时间。
OBJECTIVE：To investigate the pharmacokinetic characteristics of puerarin and puerarin lobate extract in rats and compare the difference of pharmacokinetic behavior of them. METHODS：24 SD rats were randomly divided into high-dose and low-dose groups of puerarin（300,100 mg/kg）and puerarin lobate extract（equal to 300,100 mg/kg of puerarin）. 0.2 ml blood sample were collected from posterior venous plexus of bulbus oculi before intragastric administration and 0.083,0.17,0.33,0.5,0.67,1,1.5,2,3,4,6,8,10 h after administration,respectively. The pharmacokinetic parameters were calculated by using DAS 3.0 software. RESULTS：Compared with puerarin high-dose group,AUC0-tand cmaxof puerarin low-dose group increased significantly,while CL decreased significantly;MRT0-tof puerarin low-dose group and puerarin lobate extract high-dose and low-dose groups decreased significantly（P0.01）. There was no statistical significance in pharmacokinetic parameters between puerarin lobate extract low-dose group and puerarin lobate extract high-dose group（P0.05）. CONCLULSIONS：There is difference in the pharmacokinetic behavior between puerarin and puerarin lobate extract in rats. Some components of puerarin lobate extrats maybe speed up the elimination of puerarin in rats,so as to shorten the average retention time of it.
出处
《中国药房》
CAS
北大核心
2016年第10期1311-1314,共4页
China Pharmacy
基金
国家自然科学基金资助项目(No.31401499)
广东省教育厅科研项目(No.2012LYM_0041)
广东省自然科学基金博士启动项目(No.S2012040006229)
广东省医学科研基金项目(No.B2012214)
关键词
葛根素
葛根提取物
药动学
大鼠
Puerarin
Puerarin lobate extract
Pharmacokinetics
Rat
