摘要
目的观察舒胃方对功能性消化不良(FD)患者胃排空率、胃动素(MTL)及一氧化氮(NO)的影响,探讨其治疗FD的作用机制。方法将90例FD患者随机分为治疗组、中成药组及西药组,每组30例。治疗组予舒胃方治疗,中成药组予木香顺气丸治疗,西药组予枸橼酸莫沙比利治疗。3组均治疗4周,比较治疗前后患者胃排空率、MTL及NO水平变化。结果 3组治疗后胃排空率、MTL及NO水平与本组治疗前比较差异均有统计学意义(P<0.05),胃排空率与MTL水平增加,NO水平下降,且治疗组治疗后增减幅度较中成药组及西药组治疗后更明显(P<0.05)。结论舒胃方能有效治疗FD,其作用机制可能与增加MTL水平,降低NO水平,恢复胃肠道运动功能,提高胃排空率有关。
Objective To observe the effect of Weishu formula on the gastric emptying rate,motilin（ MTL） and nitric oxide（ NO） in patients with functional dyspepsia（ FD）,and to study its action mechanism.Methods 90 FD patients were randomly divided into treatment,Chinese patent medicine and western medicine group,30 subjects in each group.Subjects in treatment,Chinese patent medicine and western medicine group were treated by Weishu formula,Muxiang-shunqi pills and mosapride citrate tablets respectively.The course was fourweeks in three groups.The levels of gastric emptying rate,MTL and NO before and after treatment were compared.Results There were statistical differences on gastric emptying rate,MTL and NO between before and after treatment in three groups（ P〈0.05）.The gastric emptying rate and MTL were increased,the NO was decreased,and the changes in treatment group was more obvious as compared with those in Chinese patent medicine and western m edicine group（ P〈0.05）.Conclusion Weishu formula has exact effect on the treatment of FD.Its treatment mechanism may be associated with the increase of MTL and decrease of NO,regain gastrointestinal function and to enhance gastric emptying rate.
出处
《河北中医》
2016年第2期191-193,197,共4页
Hebei Journal of Traditional Chinese Medicine
基金
河北省中医药管理局2013年度中医药类科研计划课题(编号:2013125)
