摘要
目的探讨川崎病的发病机制,研究血浆可溶型不规则趋化因子（s FKN）与川崎病及其冠状动脉损伤的关系。方法选取2014年3至12月在山西省儿童医院心血管与风湿免疫科住院并确诊为川崎病的患儿34例,根据病程分为急性期（发病11 d内）、亚急性期（发病11~21 d）;根据患儿是否伴有冠状动脉损伤,分为有冠状动脉损伤组（CAL组）、无冠状动脉损伤组（NCAL组）;正常对照组20例,选自同期在山西省儿童医院门诊部体检的健康儿童。用双抗体夹心固相酶联免疫吸附法（ELISA法）检测各组患儿血浆中s FKN浓度,根据超声心动图结果判断冠状动脉损伤,同时记录相关的临床数据,进而分析患儿血浆s FKN与川崎病及其冠状动脉损害的关系。结果定量检测表明,川崎病组患儿血浆s FKN水平高于对照组（t=8.26,P〈0.05）;川崎病急性期组患儿血浆s FKN水平高于亚急性期组（t=2.51,P〈0.05）;川崎病急性期CAL组患儿血浆s FKN水平高于NCAL组（t=12.59,P〈0.05）。相关分析显示,川崎病患儿血浆s FKN水平与冠状动脉损伤、红细胞沉降率（ESR）、C反应蛋白（CRP）呈正相关性（r=0.66,P〈0.05;r=0.63,P〈0.05;r=0.74,P〈0.05）。结论川崎病患儿血浆中的s FKN有可能参与了川崎病的发病机制,并促进其冠状动脉损伤的发生。
ObjectiveTo explore the pathogenesis of Kawasaki disease （KD） and the relationship between KD with/without coronary artery lesion （CAL） and sFractalkine.Methods Thirty-four cases of children who were diagnosed with KD in the Children＇s Hospital of Shanxi Province during the period between Mar. and Dec. 2014 were selected. They were classified into two groups based on the course of disease： the acute group and the subacute group. According to the results of ultrasonic cardiogram （UCG）, they were divided into two groups： one was with CAL, the other was without CAL. Twenty healthy children who had medical examination over the same period in the Children’s Hospital of Shanxi Province were chosen as the healthy control group. The plasma concentration of sFractalkine in the research objects were determined with the aid of double antibody sandwich enzyme-linked immunosorbent assay （ELISA） method. Judged the damage of coronary artery based on the results of UCG, record the correlative clinical data, and then analyzed the relationship between KD with/without CAL and sFractalkine.ResultsQuantitative detections shew that the plasma concentration of sFractalkine in the KD group was higher than that in the healthy control group （t=8.26,P〈0.05）; the plasma concentration of sFractalkine in the acute group was higher than that in the subacute group （t=2.51,P〈0.05）; the plasma concentration of sFractalkine of the CAL group was higher than the NCAL group （t=12.59,P〈0.05）. The correlation analysis shew that the plasma concentration of sFractalkine in KD was correlated with CAL, ESR and CRP （r=0.66,P〈0.05;r=0.63,P〈0.05;r=0.74,P〈0.05）.Conclusion The sFractalkine may partake the pathogenesis of KD and promote the formation of CAL.
出处
《中华临床医师杂志（电子版）》
CAS
2016年第6期776-779,共4页
Chinese Journal of Clinicians(Electronic Edition)
