摘要
目的运用meta分析方法系统评价红光辅助伤口愈合的效果。方法系统检索Cochrane、Pub Med、Embase、中国生物医学文献数据库（CBM）、万方数据库、中国知网、维普数据库等数据库,收集有关红光辅助伤口愈合的随机对照临床研究,检索时间为2004年12月～2014年12月。按纳入排除标准收集文献,采用Revman 5.3对提取的数据进行meta分析。计数资料和计量资料分别采用相对危险度（relative risk,RR）和标准化均数差（standardized mean difference,SMD）作为效果分析效应量,二者均以95%可信区间（confidence interval,CI）表示。结果共纳入17个研究,1 389例患者。对以伤口愈合的总有效率为评价指标的研究进行合并统计量,RR=1.21,95%CI（1.14,1.27）;对以伤口愈合时间为评价指标的研究进行合并统计量,SMD=-2.66,95%CI（-3.49,-1.83）。meta分析结果表明红光组较对照组有更高的有效率和更短的伤口愈合时间。结论本研究为红光疗法在临床中应用提供重要循证证据,对纳入研究的质量评价提示今后的临床研究应当进一步完善实验设计,提高研究方法学的质量。
Objective To evaluate the efficacy of red light assisting treatment in wound healing using meta analysis. Methods The published clinical data about red light assisting treatment on wound healing from Dec.2004 to Dec. 2014 were extracted from the databases including Cochrane database,Pub Med,EMBASE,CBM,Wanfang,CNKI and VIP database. Meta analysis was performed using the Revman 5. 3. Dichotomous and continuous data were accessed using relative risk（ RR） and standardized mean difference（ SMD）,respectively. Results According to the inclusion and exclusion criteria,17 studies and 1389 patients were included in this meta analysis. The result of meta analysis on the effective rate of wound healing indicated that the red light assisting treatment showed a significantly higher performance than the conventional therapy method[RR = 1. 21（ 95% CI,1. 14- 1. 27） ]. The result of meta analysis on healing time showed that the wound healing time in the red light group was obviously shorter than that in the conventional therapy group[SMD =- 2. 66,95% CI（- 3. 49,- 1. 83） ]. Conclusion Our study provided an important evidence for the application of red light irradiation therapy in clinic. The quality evaluation of the studies included in this paper suggested that the clinical study about the efficacy of red light assisting treatment in wound healing should be improved and performed at higher standards.
出处
《创伤外科杂志》
2016年第4期217-222,共6页
Journal of Traumatic Surgery
关键词
伤口
红光
光功能
META分析
愈合
wound
red light
light function
meta analysis
healing
