摘要
目的通过回顾性研究分析米索前列醇对剖宫产产后出血的预防效果。方法选择天津市武清区中医院2013年1月—2014年12月在行剖宫产手术后口服米索前列醇预防产后出血的产妇38例作为研究组,随机选取同时期剖宫产后给予肌肉注射缩宫素20 u患者38例为对照组。所选的两组患者均不存在凝血功能障碍、产道损伤、对米索前列醇过敏或存在其他禁忌症,亦排除较为严重的并发症及合并症。两组产妇的年龄以及孕周时间无明显差异性,不具有统计学意义(P>0.05),有可比性。结果娩出胎儿后2 h出血量比较,研究组出血量(201±62)m L,对照组出血量(260±82)m L,研究组产后出血量明显少于对照组,有统计学意义(P<0.05)。产后出血是指胎儿娩出2 h内出血量达到或超过400 m L。研究组1例发生产后出血,产后出血率2.6%,对照组3例发生产后出血,产后出血率7.9%,研究组产后出血率明显少于对照组,有统计学意义(P<0.05)。结论米索前列醇口服后可以快速被人体吸收,被转化为有活性的物质,发挥作用。应用米索前列醇预防治疗产后出血能够大大降低孕产妇的病死率,明显提高了孕产妇的生活质量。米索前列醇应用于预防治疗产后出血具有非常有价值的临床实用性、推广性。
Objective Through retrospective study we analyzed the effect of misoprostol for prevention ofpostpartum hemorrhage. Methods Our hospital in January 2013 - December 2014 cesarean sectionafter the line of oral misoprostol maternal 38 cases as the study group, randomly selected at the same timeafter cesarean section to give intramuscular oxytocin 20 u 38 patients of the control group. The selectedgroups of patients do not exist coagulation disorders, birth canal injury, allergy to misoprostol or othercontraindications exist, also ruled out more serious complications and comorbidities. Two groups ofmaternal age and gestational age was no significant difference, was not statistically significant （ P 〉0. 05） , comparable. Results The fetus was delivered after 2 h bleeding bleeding comparative study group （201 ±62） mL, the amount of bleeding in the control group （260 ±82） mL, the study group wassignificantly less than the amount of postpartum hemorrhage control group was statistically significant （ P〈 0. 05 ）. Postpartum hemorrhage refers to bleeding 2 hours fetus reaches or exceeds 400ml. StandardGroup as a broken one case of postpartum hemorrhage, postpartum hemorrhage rate of 2. 6 % in thecontrol group, three cases of postpartum hemorrhage, postpartum hemorrhage rate of 7. 9 percent, thestudy group of postpartum hemorrhage was significantly less than the control group was statisticallysignificant （ P 〈 0. 05 ） . Conclusion After oral administration of misoprostol can be quickly absorbedby the body, it is converted into active substances, play a role. Misoprostol PPH prevention andtreatment can greatly reduce the maternal mortality rate, significantly improved the quality of life ofpregnant women. Misoprostol applied to prevention and treatment of postpartum hemorrhage with a veryvaluable clinical utility, promotional.
出处
《广东微量元素科学》
CAS
2016年第4期65-68,共4页
Trace Elements Science
关键词
米索前列醇
剖宫产
产后出血
misoprostol
caesarean section
postpartum hemorrhage
