摘要
目的：探讨英夫利西单克隆抗体联合常规治疗对克罗恩病不完全性肠梗阻的疗效及预后影响。方法选取105例克罗恩病伴不完全性肠梗阻患者为研究对象，根据其入院顺序分成英夫利息单克隆抗体组（A 组，n =60）和常规对照组（B 组，n =45）两组。比对两组患者临床疗效及不良反应情况，记录其用药前后各实验室指标变化情况。结果①治疗后，A 组总有效率为85.0％，明显高于 B 组的73.3％（P ﹤0.05）；②治疗后，两组患者红细胞沉降率及 C 反应蛋白水平均明显降低，白蛋白和血红蛋白水平则显著提高（P ﹤0.05），其中 A 组变化幅度大于 B 组（P ﹤0.05）；③两组均无不良反应发生，以恶心呕吐、皮疹及头晕等轻微不良反应为主，差异未见统计学意义（P ﹥0.05）。结论对克罗恩病伴不完全性肠梗阻患者予以英夫利西单克隆抗体联合常规用药方案，疗效确切，值得临床推广。
Objective To investigate the effect of therapeutic effect and prognosis of Xidan clone antibody inflix-imab combined with conventional treatment for Crohn’s disease with incomplete intestinal obstruction. Methods One hundred and five cases of Crohn’s disease complicated with incomplete intestinal obstruction patients were chosen as re-search objects according to the order of admission into Hideo interest monoclonal antibody group（group A,n = 60）and normal control group（group B,n = 45）. Comparison of clinical curative effect and difference of adverse reaction of the two groups,recorded the changes of laboratory indexes before and after drugs. Results ①After treatment,total effective rate of group A was 85% ,which was significant higher than that of group B（73. 3% ,P ﹤0. 05）;②After treatment,the two groups of patients the erythrocyte sedimentation rate and C-reactive protein level were obviously decreased,albumin and hemoglobin levels were significantly increased（P ﹤0. 05）,the changes of group A was greater than group B（P ﹤ 0. 05）;③ The two groups had no adverse reaction,with nausea and vomiting,rash and dizziness slight adverse reaction,which had no signifi-cant difference（P ﹥0. 05）. Conclusions The effect of infliximab polyclonal antibody combined with conventional on incom-plete intestinal obstruction of Crohn’s disease is exact,so it is worthy of the clinical promotion.
出处
《中国实用医刊》
2016年第4期36-37,共2页
Chinese Journal of Practical Medicine
关键词
英夫利西单克隆抗体
常规治疗
克罗恩病
不完全性肠梗阻
Infliximab polyclonal antibody
Conventional treatment
Crohn’s disease
Incomplete intestinal obstruction
