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幽门螺杆菌感染与颈动脉粥样硬化关系研究 被引量:7

Study on the relationship between Helicobacter pylori infection and carotid atherosclerosis
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摘要 目的初步探讨幽门螺杆菌(Hp)感染与颈动脉粥样硬化的关系。方法选择2014年1月至2015年6月间我院体检者310例。入选人群均进行血压、血脂、血糖、血清超敏C反应蛋白(hs-CRP)、脂蛋白相关磷脂酶A2(Lp-PLA2)、颈动脉彩色超声和^13C-尿素呼气试验(^13C—UBT)检测。按照^13C—UBT检测结果分为Hp感染组和非Hp感染组,通过比较分析两组间颈动脉粥样硬化情况,以及Hp感染对颈动脉粥样硬化患者hs-CRP、Lp-PLA2水平的影响。结果Hp感染组hs-CRP、Lp-PLA2值均明显高于非Hp感染组(P〈0.05);Hp感染组的颈动脉粥样硬化发生率为59.6%,明显高于非Hp感染组44.3%(P〈0.05);Hp感染组不稳定斑块发生率38.5%明显高于非Hp感染组发生率25.8%(P〈0.05)。结论Hp感染与颈动脉粥样硬化呈明显相关性,Hp感染可引起颈动脉粥样硬化斑块内局部的长期炎性反应,增加斑块的不稳定性。 Objective To investigate the relationship between Heli-cobacter pylori(Hp) infection and carotid atherosclerosis. Methods From January 2014 to June 2015,310 cases of physical examinati on in our hospital. All the selected patients were tested for blood pressure, blood lipid, fasting blood glucose, high sensitivity C reactive protein level (hs-CRP), lipoprotein associated phospholipase A2 level ( Lp-PLA2), carotid color Doppler ultrasound and ^13C-urea breath test (^13C-UBT). In accordance with ^13C-UBT detection results for HP infection group( observation group) and HP non infection group( control group) by comparative analysis between the two groups of carotid atherosclerosis,and HP infection of carotid atherosclerosis in patients with serum hs-CRP level,Lp-PLA2 level of influence. Results The HP infection group, hs-CRP,Lp-PLA2 value was significantly higher than that in non HP infection group(P 〈0.05 ), compare the differences between the two groups have statistical significance; HP infection group, the incidence of carotid atherosclerosis was 59.6%, significantly higher than that in the HP non infection group 44.3% ,the difference is statistically significant( P 〈 0. 05 ) ;HP infection group unstable plaque incidence rate of 38.5% were significantly higher than that of HP non-infection group, the incidence rate of 25.8% ,the difference is statistically significant ( P 〈0. 05 ). Conclusion Hp infection and carotid atherosclerosis were significantly correlated, Hp infection can cause local inflammatory reaction in carotid atherosclerosis plaque,increase the instability of plaques.
作者 王集华
出处 《临床内科杂志》 CAS 2016年第3期192-194,共3页 Journal of Clinical Internal Medicine
关键词 幽门螺杆菌 颈动脉粥样硬化 不稳定斑块 Helicobacter pylori Carotid atherosclerosis Unstable plaque
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  • 1Touboul PJ, Hennerici MG, Meairs S, et al. Mannheim intima-media thickness consensus [ J ]. Crbrovasc Dis,2004,18 ( 4 ) :346-349.
  • 2陈文实,张锋,丁中,张燕.彩色多普勒超声在颈动脉粥样硬化斑块诊断中的应用[J].临床合理用药杂志,2009,2(7):1-3. 被引量:14
  • 3陈星海,王育珊,王江滨.幽门螺杆菌感染诱发动脉粥样硬化的机制[J].中国免疫学杂志,2007,23(7):671-672. 被引量:16
  • 4Amefiso SF, Ffidman EA,Leiguarda RC et al. Detection of Helieobacter pylori in hum-an carotid atheroselerotic plaques [ J ]. Stroke, 2009,32 (2) :385-391.
  • 5Latsios G, Saetta A, Michalopoulos NV, et al. Detection of cytomegalov- irus, Helieobaeter pylori and Chlamydia pneumoniae DNA in cardioath- erosclerotie plaque by the polym erase chain reaction [ J ]. Aeta Cardiol, 2004,59 (6) :652-657.
  • 6Franceschi F, Sepulveda AR, Gasbarrini A, et al. Cross-reactivity of anti-CagA antibodies with vascular wall antigens [ J ]. Circulation, 2008,106 (4) :430-434.
  • 7Mayr M, Kiechl S, Willeit J, et al. Infections, immunity, and atheroscle- rosis: associations of antibodies to Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus with immune reactions to heat-shock protein 60 and carotid or femoral atherosclerosis [ J ]. Circulation, 2000, 102 (8) :833-839.
  • 8Saijo Y ,Utsugi M ,Yoshioka E et al. Relationship of Helicobaeter pylori infection to arterial stiffness in Japanese subjects [ J ]. Hypertens Res, 2005,28 (4) :283 -292.
  • 9王成,刘艳宾,韩明磊.幽门螺杆菌感染与冠心病发病的相关性研究[J].中华医院感染学杂志,2014,24(14):3526-3527. 被引量:12
  • 10Cassar K, Bachoo P, Ford I, et al. Helicobacter pylori seropositivity is associated with enhanced platelet activation in patients with intermittent claudication [ J ]. J asc Surg,2004,39 ( 3 ) : 560-564.

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