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非小细胞肺癌与小细胞肺癌相关副肿瘤综合征的临床特征比较分析 被引量：2

Comparison of clinical characteristics of paraneoplastic syndrome related to non-small lung cancer and small cell lung cancer
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摘要 目的:分析非小细胞肺癌(NSCLC)与小细胞肺癌(SCLC)合并副肿瘤综合征(PNS)的临床特征,识别警示症状。方法:回顾分析病理确诊的NSCLC合并PNS 14例(其中男12例),记录人口学资料、临床病史、血和脑脊液的相关神经元抗体、病理结果及治疗情况,并与同期住院的SCLC合并PNS 52例进行比较。结果:NSCLC组较SCLC组患者发病年龄更晚。NSCLC组PNS亚型:周围神经病9例(64.29%),肌病2例(14.29%),Lambert-Eaton综合征1例(7.14%),边缘叶脑炎1例(7.14%)。全部患者均表现为单一临床亚型。非神经系统PNS为肺性骨病2例(14.29%)。SCLC组PNS亚型:Lambert-Eaton综合征36.17%,周围神经病34.04%,亚急性小脑变性21.28%,边缘叶脑炎17.02%,脑干病变4.26%,肌病2.13%。7例(14.89%)多种亚型同时存在。非神经系统PNS为抗利尿激素分泌不当综合征8例(15.38%)。SCLC组、NSCLC组抗神经元抗体阳性率为56.00%(14/25)和16.67%(1/6)。结论:NSCLC合并PNS临床亚型分布特征以及抗神经元相关抗体与SCLC不同。 Objective ：To compare the clinical characteristics of para-neoplastic syndrome（PNS）related to non- small lung cancer （NSCLC）and small cell lung cancer （SCLC）.Methods：Fouteen pathologic confirmed NSCLC cases who met the diagnostic criteria for PNS（12 male cases）were analyzed and compared with 52 contempo- rary hospitalized SCLC cases vcith PNS.Demographic data,clinical history,antineural antibodies,pathologic re- sults and treatment were recorded.Results：The age at onset was older in the NSCLC group than in SCLC group.The prevalence of neurologic PNS in NSCLC group were：peripheral neuropathy 9 cases （64.29%）,my- opathy 2 cases（14.29%）,Lambert-Eaton syndrome 1 case（7.14%）,limbic encephalitis 1 case（7.14%）.All cases only presented as unique subtype.Two cases（14.29%）presented bone disease.The prevalence of neurologic PNS in SCLC group were ： Lambert-Eaton syndrome （36.17%）, peripheral neuropathy （34.04%）, sub-acute cerebellar degeneration （21.28%）, limbic encephalitis （ 17.02% ）, brain stem lesions （4.26%） and myopathy （2.13% ）.Two sub- types co-existed in 7 cases（14.89%）.Eight cases（15.38%）presented syndrome of inappropriate secretion of an- tidiuretic hormone.There were 56%（14/25） antineural antibodies positive in SCLC group with exclusively anti- Hu antibody and 16.67%（1/6）in NSCLC group.Conclusion：NSCLC and SCLC patients with PNS have different clinical characteristics and positive anti-neural antibody rate.
作者 袁晶 周立新 关鸿志 倪俊 崔丽英 李单青 刘洪生
机构地区 中国医学科学院 中国医学科学院神经科学中心 中国医学科学院
出处 《中日友好医院学报》 2016年第2期80-83,共4页 Journal of China-Japan Friendship Hospital
关键词 副肿瘤综合征 肺癌 小细胞肺癌 非小细胞肺癌 paraneoplastic syndrome lung cancer small cell lung cancer non small cell lung cancer
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献15

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二级参考文献57

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二级引证文献8

中日友好医院学报
2016年 第2期

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