摘要
目的:探讨滋阴补肾方对肾阴虚型围绝经期综合征(PMS)患者的临床疗效及可能的作用机制。方法:采用随机、平行对照研究,将符合观察标准的PMS患者随机分为治疗组与对照组,治疗组服用滋阴补肾方,对照组服用更年安片,疗程8周。观察临床疗效与症状改善情况,检测治疗前后血清雌激素、外周血单核细胞雌激素受体及其比值等指标变化。结果:两组在综合疗效方面无显著性差异(P>0.05),但治疗组在改善腰膝酸软、眩晕、耳鸣耳聋、五心烦热、口干咽燥等证候积分方面明显优于对照组(P<0.05或P<0.01)。与对照组比较,治疗组可明显提高血清雌激素水平(P<0.01),并对外周血单个核细胞中雌激素α受体(ERα)水平及其与雌激素β受体(ERβ)的比值有显著影响(P<0.01或P<0.05)。结论:滋阴补肾方对肾阴虚型PMS疗效确切,并可能通过影响雌激素效应的发挥而产生治疗作用。
Objective： To investigate the clinical effect and therapeutic mecanism of Kidney-Yin Tonifying Prescription（ KYTP） to treat perimenopausal syndrome differentiated as Kidney-Yin deficiency type. Methods： A randomized,paralle1 controlled trial was conducted,and the patients in conformity with the observation standards were randomly divided into treatment group and control group,the treatment group were treated with KYTP and the control group with Gengnian＇an,the course of treatment was 8 weeks. Before and after treatment,the effect value,the changes of symptom scores,serum estrogen,estrogen receptors（ ERs） and their ratio in peripheral blood mononuclear cell were observed. Results： There was no significance in effect value between two groups（ P 0. 05）,but KYTP could significantly relieve such symptoms scores as soreness and weakness of waist and knees,dizzy,tinnitus,five upset hot,dry mouth and throat etc.（ P 0. 05 or P 0. 01）,meanwhile obviously increased serum estrogen levels（ P 0. 01）,and ER alpha level and ER alpha / ER beta ratio in peripheral blood mononuclear cells（ P 0. 05 or P 0. 01）. Conclusion： KYTP had accurate effect on perimenopausal syndrome patiens differentiated as Kidney-Yin deficiency type,and might play a role of influencing the exerting of estrogen effects.
出处
《上海中医药大学学报》
CAS
2016年第2期27-30,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
上海市中医药事业发展三年行动计划临床优势专科建设项目(ZYSNXD-YL-YSZK023)
上海市卫生局中医药科研基金资助项目(2012L070A)
上海市浦东新区中医药事业发展专项基金项目(PDYNZJ2014-01)
关键词
滋阴补肾方
围绝经期综合征
雌激素
雌激素受体
Kidney-yin Tonifying Prescription
perimenopausal syndrome
estrogen
estrogen recepto
