摘要
目的：比较艾盐包热熨穴位联合盐酸托烷司琼与单独给予盐酸托烷司琼防治顺铂化疗所致的消化道反应的疗效差异。方法：招募符合纳入标准、首次接受化疗的恶性肿瘤患者60例，随机分成观察组和对照组，各30例。化疗第1～5天，对照组每日给予盐酸托烷司琼5mg静脉推注，观察组在对照组的基础上每日给予艾盐包热熨中脘穴。比较两组患者化疗第1～5天每天的恶心、呕吐情况和化疗开始后1周内便秘、头晕等化疗不良反应的发生率。结果：观察组化疗第2～5天每天的恶心控制有效率高于对照组（均P〈0．05）；化疗第3～5天每天的呕吐控制有效率高于对照组（均P〈0．05）；化疗开始后1周内便秘发生率低于对照组（P〈0．05）。结论：艾盐包热熨穴位联合盐酸托烷司琼较单独给予盐酸托烷司琼能更有效减轻含顺铂化疗方案所致的恶心呕吐，降低迟发型呕吐的发生率，对缓解化疗后便秘的效果也较好。
Objective To compare the efficacy between moxa salt packets at acupoints combined with tropise- tron hydrochloride and single use of tropisetron hydrochloride for cisplatin chemotherapy-induced gastrointestinal reaction. Methods Sixty patients with malignant tumor who met inclusive criteria and received chemotherapy for the first time were recruited and randomly divided into an observation group and a control group, 30 cases in each one. Between the first days and fifth day into the chenaotherapy, the patients in the control group were treated with daily intravenous injection of tropisetron hydrochloride （5 mg）, while patients in the observation group, based on the treatment of control group, were treated with moxa salt packets at Zhongwan （CV 12）. The nausea and vomiting between the first days and fifth day into the chemotherapy were compared in the two groups, and the occurrence rates of adverse reactions within the first week into chemotherapy were recorded. Results Between the second day and fifth day into the chemotherapy, ＂the effective rate for nausea in the observation group was higher than that in the control group （all P〈0.05） ; between the third day and fifth day into the chemotherapy, the effective rate for vomiting in the observation group was higher than that in the control group （all P〈0.05） ; one week into the chemotherapy, the occurrence rate of constipation in the obserwition group was lower than that in the control group （P〈0.05）. Conclusion The moxa salt packets combined with tropisetron hydroehloride can effectively re- duce the cisplatin chemotherapy-induced nausea and vomiting as well as the occurrence rate of delayed type vomi- ting, and improve the constipation, which is superior to single use of tropisetron hydrochloride.
出处
《中国针灸》
CAS
CSCD
北大核心
2016年第4期405-408,共4页
Chinese Acupuncture & Moxibustion
关键词
顺铂化疗
艾盐包
穴位热熨
恶心
呕吐
cisplatin chernotherapy
moxa salt packets
hot compressing at acupoints
nausea
vomiting
