摘要
目的研究梅毒血清固定患者趋化因子受体CCR3、CCR5、CXCR4、CXCR3水平,探讨梅毒患者免疫功能的变化。方法检测梅毒血清固定患者(血清固定组)35例外周血趋化因子受体CCR3、CCR5、CXCR4、CXCR3水平,并以规范治疗后梅毒血清反应素试验血清转阴者梅毒患者(转阴组)40例及健康体检者(健康组)35例分别作为对照。比较3组外周血趋化因子受体水平。结果梅毒血清固定患者CCR3表达高于健康组及转阴组,CCR5、CXCR3表达低于健康组及转阴组,差异均有统计学意义(P<0.01)。转阴组与健康组比较,趋化因子受体表达差异无统计学意义(P>0.05)。结论趋化因子受体在梅毒血清固定患者的发病、发展中可能起着重要作用。
Objective To investigate chemokine receptors levels in peripheral T-lymphocytes of patients with seroresistance syphilis. Methods The chemokine receptors CCR3, CCR5, CXCR4, CXCR3-expressing T-lymphocytes were detected in 40 patients with seroresistance syphilis, 40 patients with negative results after treatment and 35 healthy adults as controls. Results The expression of CCR3 on CD4^＋ T cells was increased, the expression of CCR5 and CXCR3 was declined in peripheral blood of seroresistance syphilis in comparison with those of the healthy subjects and patients with negative results after treatment （P〈0.01）. Conclusion The chemokine receptors may be involved in the onset, development of seroresistance syphilis.
出处
《浙江医学》
CAS
2016年第5期345-347,共3页
Zhejiang Medical Journal
基金
温岭市科技计划项目(2012WLCA0071)
关键词
梅毒
趋化因子受体
血清固定
Syphilis Chemokine receptor Seroresistance
