摘要
目的:研究消瘿散结胶囊的抑瘤、抗炎作用,从而进一步探讨消瘿散结胶囊治疗甲状腺腺瘤的作用机理。方法:制造S180肉瘤小鼠模型和小鼠耳肿胀模型,消瘿散结胶囊和对照药物(逍遥丸)治疗后,取标本称重,分别计算抑瘤率和耳肿胀率。结果:消瘿散结胶囊在不同剂量下均有一定的抑瘤作用,消瘿散结胶囊抑瘤作用以高剂量组作用最明显,疗效优于对照药(逍遥丸)组(P<0.05);消瘿散结胶囊大剂量组能显著抑制由二甲苯引起的小鼠耳廓肿胀,与常水组比较P<0.05。结论:消瘿散结胶囊治疗甲状腺腺瘤的机理可能与其抑瘤、抗炎作用有关。
Objective： To research the anti-tumor,anti-inflammatory function of Xiaoying Sanjie capsule,thereby further investigating the mechanism of Xiaoying Sanjie capsule in the treatment of thyroid adenoma. Methods： To develop S180 mouse sarcoma model and ear edema model. After giving Xiaoying Sanjie capsule and control drugs（ Xiaoyao pill）,test the weight,anti-tumor and ear edema rate of the models. Results： Xiaoying Sanjie capsule has inhibition on tumor and edema at different doses. It is more effective at higher dose,and this is significant when compared with the control group（ P〈0. 05）. Compared with the control group,Xiaoying Sanjie capsule high dose group can significantly inhibited the mice＇ ear edema induced by xylene（ P〈0. 05）.Conclusion： The mechanism of Xiaoying Sanjie capsule in the treatment of thyroid adenoma may relate to its anti-tumor and anti-inflammatory effects.
出处
《世界中医药》
CAS
2016年第1期120-122,共3页
World Chinese Medicine
基金
济南市卫生局科技发展计划(编号:2007-54)
关键词
消瘿散结胶囊
抗炎
抑瘤作用
Xiaoying Sanjie capsule
Anti-inflammation
Anti-tumor
