摘要
目的观察葡萄籽原花青素（GSPE）对中老年阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的治疗效果。方法选择华北理工大学附属医院2012年12月至2014年12月收治的101例中老年OSAHS患者，按随机数字表法分为对照组（36例）、GSPE组A（36例）与GSPE组B（36例）。3组患者均采用多导睡眠图（PSG）监测睡眠呼吸暂停低通气指数（AHI）、快速动眼运动睡眠（REM）、微觉醒指数（MAI）；采用疲劳严重程度量表（FSS）和Epworth嗜睡量表（ESS）评测患者的疲劳度、嗜睡程度；双抗体夹心酶标免疫分析法测定治疗前、后血丙二醛（MDA）和超氧化物歧化酶（SOD）水平。对照组给予持续气道正压通气（CPAP）治疗；GSPE组A和GSPE组B在此基础上分别给予高、低剂量GSPE口服治疗。结果治疗前，3组患者AHI、REM、MAI、FSS评分、ESS评分、血清MDA和SOD比较差异均无统计学意义（P均〉0．05）。治疗后，GSPE组B患者FSS评分、ESS评分、MAI、MDA含量[分别为（2．27±0．84）分、（6．20±1．16）分、（8．42±3．27）次／h、（69．40±13．70）nmol／L]分别低于GSPE组A[分别为（3．84±1．20）分、（8．14±1．26）分、（10．34±3．48）次／h、（85．38±12．22）nmo]／L]及对照组[分别为（5．02±1．14）分、（9．40±1．14）分、（13．38±4．08）次／h、（97．96±13．24）nmol／，差异均有统计学意义（P均为0．000）：GSPE组BREM（18．28±2．54）％高于GSPE组A（15．74±4．32）％和对照组（12．38±3．77）％，差异具有统计学意义（P=0．000）；3组间SOD水平比较差异无统计学意义（P〉0．05）。对照组、GSPE组A、GSPE组B有效率分别为70．5％、79．4、90．9％，GSPE组B有效率显著高于对照组、GSPE组A，差异有统计学意义（P均〈0．05）。结论GSPE可改善中老年OSAHS患者睡眠质量，清除机体氧自由基水平，对中老年OSAHS患者有较好的治疗效果。
Objective To observe the effect of grape seed proanthocyandin extract （GSPE） on aged patients with obstructive sleep apnea-hypopnea syndrome（OSAHS）. Methods One hundred and one cases aged patients with OSAHS who were treated in the Affiliated Hospital of North China University of Science and Technology from December 2012 to December 2014 were randomly divided into control group, GSPE group A and GSPE group B, 36 cases of each group. The apnea hypopnea index（AHI）, rapid eye movement （REM） and micro-arousal index （MAI） were observed by polysomnography （PSG） ; the fatigue, sleepiness of patients were conducted with fatigue severity scale （FSS） and epworth sleepiness scale （ESS）; the peripheral blood malondialdehyde（MDA） levels and superoxide dismutase （SOD） level of before and after treatment were observed by enzyme-linked immunosorbent （ELISA） method. The control group received continuously positive airways pressure （CPAP） treatment, while GSPE group A and GSPE group B received low and high dose of GSPE treatment oral besides CPAP respectively. Results Before the treatment, there were no significant differences in the terms of AHI, REM, MAI, FSS, ESS, MDA and SOD among the three groups （P〉0. 05）. After treatment, the scores of FSS, ESS, MAI and M DA in GSPE group B were （2. 27±0. 84）points, （6. 20± 1.16） points, （8.42±3.27） times/h, （ 69.40± 13.70） nmol/L respectively, lower than that of GSPE group A （ （ 3.84 ± 1.20） points, （ 8. 14± 1.26） points, （ 10. 34±3.48） times/h, （ 85.38± 12. 22） nmol/L respectively） and control group （ （ 5.02± 1.14 ） points, （ 9.40 ± 1.14 ） points, （ 13.84 ± 4. 08 ） times/h, （ 97. 96 ± 13.24 ） nmol/L respectively）, the differences were significant （ P = 0. 000）. The REM in GSPE group B was （ 18.28 ± 2. 54） %, higher than that of GSPE group A （ （ 15.74 ± 4. 32 ） % ） and control group （ （ 12. 38 ±3.77 ） % ）, there weresignificant differences among the three groups（P= 0. 000）. While there were no significant differences on SOD levels among the three groups（P〉0. 05）. The rate of effectiveness in control group,GSPE group A and GSPE B were 70. 5% ,79.4% and 90. 9% respectively, the rate of effectiveness in GSPE B was significant higher than GSPE group A and control group,and the difference was significant（P〈0. 05）. Conclusion GSPE can improve the sleep quality and weaken oxidative stress reaction, and has a good clinical effects for aged patients with OSAHS.
出处
《中国综合临床》
2016年第3期195-199,共5页
Clinical Medicine of China
基金
河北省医学科学研究重点课题（ZD20140500）
