摘要
通过模拟临床使用一次性输液器输注盐酸头孢替安,对一次性使用输液器中可沥滤物进行了气相色谱-质谱分析。研究使用了两个不同厂家生产的A、B两种型号的一次性使用输液器,其中A型输液器中检出环己酮、2-乙基己醇,浓度分别达到了5.166μg/mL和0.4716μg/mL;B型输液器中检出环己酮、2-乙基己醇和2-苯基-2-丙醇,浓度分别达到了3.741μg/mL、0.0827μg/mL和0.1939μg/mL。另外,两种型号的一次性使用输液器中均检出少量邻苯二甲酸(2-乙苯已基)酯(DEHP)溶出,其溶出量分别为0.97μg/set和1.05μg/set。
The leachable substances after infusion of cefotiam hydrochloride in disposable infusion set were analyzed by gas chromatogrophy-mass spectrometry（GC-MS）.In this study,we used two types of disposable infusion sets from different manufacturers.Cyclohexanone and 2-ethyl hexanol were detected in type A,and the concentrations were 5.166μg/mL and 0.4716μg/mL,respectively.Cyclohexanone,2-ethyl hexanol and 2-phenyl-2-propanol were detected in type B,and the concentrations were 3.741μg/mL,0.0827μg/mL and 0.1939μg/mL,respectively.Moreover,a small amount of diethylhexyl phthatate（DEHP）was detected in both of the two different disposable infusion sets with the concentration of 0.97μg/set and 1.05μg/set in type A and type B,respectively.
出处
《分析科学学报》
CAS
CSCD
北大核心
2016年第2期239-243,共5页
Journal of Analytical Science
基金
国家科技支撑计划(No.2012BAI22B03)
