亚临床甲状腺功能减退症与动脉粥样硬化的相关性被引量：5

Relationship analysis between subclinical hypothyroidism and atherosclerosis

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摘要目的探讨亚临床型甲状腺功能减退症(subclinicalhypothyroidism,SCH)与动脉粥样硬化之间的关系。方法选取SCH患者80例,同时选取甲状腺功能正常的健康志愿者80例作为对照组,比较两组甲状腺功能相关指标:促甲状腺激素(TSH)、血清游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4);动脉粥样硬化相关指标:高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、血栓素B2(TXB2)、C反应蛋白(CRP)、颈动脉中层厚度(cIMT)的变化,并对各指标的相关性进行研究。结果SCH组TSH、LDL-C、TC、TXB2及cIMT明显高于对照组(P<0.01);Pearson相关分析显示,TSH与TC、LDL-C、TXB2、cIMT呈正相关;多元线性回归分析结果显示,cIMT与LDL-C、TSH独立相关。结论 SCH患者血清中高水平TSH与动脉粥样硬化的发生存在一定的相关性。 Objective To explore the relationship between subclinical hypothyroidism（SCH） and atherosclerosis.Methods Eighty patients with SCH and eighty volunteers with euthyroidism were contained in the study as SCH group and control group,respectively.All indicators were examined as follows：thyroid function-related indicators such as TSH,FT3 and FT4;atherosclerosis-related indicator such as HDL-C,LDL-C,TC,TG,TXB2,CRP and cIMT.Correlation study was performed between indicators.Results The levels of TSH,LDL-C,TC and TXB2 in SCH group were significantly higher than those of control group（P〈0.01）.Pearson correlation analysis showed that TSH level was positively correlated with TC,LDL-C,TXB2 and cIMT level.Multivariate regression analysis showed that cIMT was independently correlated with LDL-C and TSH.Conclusion There appeared some correlation bteween the high level of TSH in patients with SCH and the development of atherosclerosis

作者郭妮甘振钊苏庆建

机构地区广西医科大学第三附属医院内分泌科广西医科大学第三附属医院心血管内科

出处《临床荟萃》 CAS 2016年第4期386-388,共3页 Clinical Focus

基金广西南宁市科学研究与技术开发计划项目资助(NO.2007011410C)

关键词甲状腺功能减退症促甲状腺素动脉粥样硬化 hypothyroidism thyrotropin atherosclerosis

分类号 R581.2 [医药卫生—内分泌]

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