摘要
目的提高对DKA为初发表现的年轻、超重/肥胖T2DM患者的认识,并探讨减少此种急症的措施。方法回顾性分析4例以DKA为首发表现的年轻、超重/肥胖T2DM患者的临床特点并复习相关文献。结果 4例患者均为年轻男性（年龄14-31岁）,有糖尿病家族史、长期大量饮用碳酸饮料的不良饮食史,长期超重/肥胖,均为急性起病（病程8-14 d）,以DKA（pH 7.00-7.16）为首发表现,入院时胰岛功能差（FC-P 269.2-469.6 pmol/L）,经治疗后胰岛功能迅速恢复,此后以生活方式干预联合二甲双胍治疗,血糖控制良好（HbA1 c 5.5%-6.3%）。结论在超重/肥胖的青少年人群中（特别是有糖尿病家族史）应积极筛查糖尿病,以减少DKA及其他糖尿病慢性并发症发生。
Objective To improve the diagnosis and treatment of DKA as an initial manifestation in young overweight or obese T2 DM patients in order to reduce the occurrence of such emergency.Methods Clinical characteristics of four overweight or obese T2 DM patients with DKA as early manifestation were analyzed retrospectively.and related literature was reviewed.Results All four patients were young men（14-31 years）,with family history of diabetes,unhealthy diet history of too much carbonated drinking and being obese for a long time;acute onset（diseases duration 8-14 d）.presenting as DKA（Arterial pH 7.00-7.16） and poor islet function.However,their islet function recovered quickly after treatment and their blood glucose were controlled by lifestyle intervention and metformin treatment（HbA1c 5.5%-6.3%）.Conclusion T2 DM should be actively screened in overweight or obese adolescents,especially with family history of diabetes,to reduce the risk of DKA and other diabetic chronic complications.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2016年第4期367-370,共4页
Chinese Journal of Diabetes
基金
国家自然科学基金(81370947)
南京市医学科技发展项目(YKK11092
YKK14055)
南京市科委课题(2013ZD005)
2013南京内分泌代谢病临床医学中心项目
关键词
糖尿病酮症酸中毒
糖尿病
2型
超重/肥胖
Diabetic ketoacidosis（DKA）
Diabetes mellitus
type 2
Overweight/obesity
