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普拉洛芬治疗角结膜干燥症的疗效观察 被引量:9

Observation on Efficacy of Pranoprofen in Treatment of Keratoconjunctivitis Sicca
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摘要 目的:探讨普拉洛芬治疗角结膜干燥症的临床疗效。方法:选取荆州第二人民医院2013年6月—2014年12月收治的120例角结膜干燥症患者,按随机数字表法分为2组各60例。对照组患者给予人工泪液方案治疗,观察组患者给予普拉洛芬滴眼液治疗;治疗2周后,比较2组患者的临床疗效,自觉症状评分、泪眼破膜时间(break-up time,BUT)试验结果、角膜荧光素染色、希尔默(schirmer)试验结果及不良反应发生情况。结果:观察组患者总有效率为96.7%(58/60),对照组为63.3%(38/60),2组的差异有统计学意义(P<0.05);观察组患者自觉症状评分(14.1±2.0)分、BUT试验(12.3±1.5)s及角膜荧光素染色分级(0.8±0.2)级,与对照组的(16.9±1.5)分,(9.2±1.2)s,(1.6±0.3)级比较,差异有统计学意义(P<0.05);观察组患者Schirmer试验结果为(4.6±1.5)mm,与对照组的(5.2±1.9)mm比较,差异无统计学意义(P>0.05)。2组患者均无不良反应发生。结论:应用普拉洛芬方案治疗角结膜干燥症有效率高,临床症状及体征改善明显,安全性高,值得推广。 OBJECTIVE: To probe into the clinical efficacy of pranoprofen in treatment of keratoconjunctivitis sicca. METHODS: 120 cases with keratoconjunctivitis sicca admitted into Jingzhou the Second People's Hospital from Jun. 2013 to Dec. 2014 were selected to be divided in to two groups via the random number table,with 60 cases in each. The control group were treated with artificial tears therapy while the observation group received pranoprofen eyedrops scheme. After treatment of two weeks,the clinical efficacy,signs comprehensive score,BUT test,corneal fluorescence staining,outcome of Schirmer test and incidence of adverse drug reactions were compared between two group of patients. RESULTS: The total effective rate of observation group was 96. 7%( 58 /60) and the control group was 63. 3%( 38 /60), with statistically significant difference( P〈0. 05). In observation group, the signs comprehensive score was( 14. 1 ± 2. 0),BUT test was( 12. 3 ± 1. 5) s and the corneal fluorescence staining was( 0. 8 ± 0. 2),compared with the control group( 16. 9 ± 1. 5),( 9. 2 ± 1. 2) and( 1. 6 ± 0. 3),the difference was statistically significant( P〈0. 05). The outcome of Schirmer test of observation group was( 4. 6 ± 1. 5) mm,compared with the control group( 5. 2 ± 1. 9) mm,the was not statistically significant( P〉0. 05). Meanwhile,there was no adverse drug reaction in two group of patients. CONCLUSIONS: The regimen of pranoprofen in treatment of keratoconjunctivitis sicca is effective,and the clinical symptoms and signs have been significantly improved with high security. It is worthy to of promotion and application.
作者 寇亚
出处 《中国医院用药评价与分析》 2016年第3期315-317,共3页 Evaluation and Analysis of Drug-use in Hospitals of China
关键词 普拉洛芬滴眼液 角结膜干燥症 效果 Pranoprofen eye drops Keratoconjunctivitis sicca Effects
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