摘要
目的：探讨硫酸镁与硫酸特布他林雾化液联合雾化吸入治疗小儿哮喘的临床疗效。方法：选取上犹县妇幼保健院2010年9月—2013年9月收治的小儿哮喘患儿82例,按随机数字表法分为2组各41例。对照组患儿在对症治疗基础上联合硫酸特布他林进行雾化吸入治疗;观察组在对照组治疗基础上联合硫酸镁治疗,2组患儿均连续治疗3~7 d。治疗结束后,对2组患者儿的治疗效果及不良反应进行比较。结果：观察组患儿总有效率为100.00%（41/41）;对照组为78.05%（32/41）,2组的差异有统计意义（P〈0.05）。观察组患儿心率为（108.00±12.00）次/min,呼吸频率（29.00±6.00）次/min,舒张压（7.20±0.60）k Pa,收缩压（11.20±0.80）k Pa,与对照组的（110.00±11.00）、（28.00±6.00）次/min,（7.10±0.60）、（11.10±0.90）k Pa比较,差异无统计学意义（P〉0.05）;观察组患儿呼气峰流速值为（202.00±45.00）L/min,高于对照组的（154.00±43.00）L/min,差异有统计学意义（P〈0.05）。观察组患儿出现头痛2例,恶心2例,不良发生发生率为9.76%（4/41）;对照组出现头痛2例、恶心1例,不良反应发生率为7.32%（3/41）,2组的差异无统计学意义（P〉0.05）。结论：硫酸镁与硫酸特布他林雾化液联合雾化吸入治疗小儿哮喘效果较好,能有效改善患儿临床症状,且安全性较高,可推广。
OBJECTIVE： To probe into the clinical efficacy of magnesium combined with terbutaline aerosol liquid in combination inhaling treatment of children with asthma. METHODS： 82 cases of children with asthma admitted into Shangyou County Maternal and Child Health Hospital from Sept. 2010 to Sept. 2013 were selected to be divided into two groups via the random number table,with 41 cases in each. Two group of patients were treated with conventional symptomatic treatment of anti-infection and oxygen inhalation,the control group were given terbutaline of combination inhaling treatment based on the symptomatic treatment; and the observation group additionally received magnesium of combination inhaling treatment based on the control group 2 groups of children were treated for 3 - 7 days. After treatment,the treatment effects and adverse drug reactions were compared between two group of patients. RESULTS：The total effective rate of observation group was 100. 00%（ 41 /41） and the control group was 78. 05%（ 32 /41）,with statistically significant difference（ P〈0. 05）. In observation group,the heart rate was（ 108. 00 ± 12. 00） times / min,the respiratory rate was（ 29. 00 ± 6. 00） times / min,the diastolic blood pressure was（ 7. 20 ± 0. 60） k Pa,the systolic blood pressure was（ 11. 20 ± 0. 80） k Pa,compared with the control group（ 110. 00 ± 11. 00）,（ 28. 00 ± 6. 00）,（ 7. 10 ± 0. 60） and（ 11. 10 ± 0. 90）,the difference was not statistically significant（ P〈0. 05）. The peak expiratory flow of observation group was（ 202. 00 ± 45. 00） L / min,higher than that of control group（ 154. 00 ± 43. 00） L / min,with statistically significant difference（ P〈0. 05）. In observation group,there were 2 cases of headache,2 cases of nausea,and the incidence of adverse drug reactions was 9. 76%（ 4 /41）; and in control group were 2 cases of headache,1 case of nausea,and the incidence of adverse drug reactions was 7. 32%（ 3 /41）,with no statistically significant difference（ P〈0. 05）. CONCLUSIONS： The clinical efficacy of magnesium combined with terbutaline aerosol liquid in combination inhaling treatment of children with asthma is significant,which can effectively improve the clinical symptoms of patients and has higher safety. It is worthy of promotion.
出处
《中国医院用药评价与分析》
2016年第3期319-321,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
硫酸镁
硫酸特布他林雾化液
雾化吸入
小儿哮喘
效果
Magnesium
Terbutaline aerosol liquid
Aerosol inhalation
Children with asthma
Effect
