摘要
目的：探讨早期宫颈癌宫旁组织转移的相关危险因素。方法：回顾性分析2010年3月—2015年8月瑞安市塘下人民医院诊治的890例宫颈癌患者的临床病理资料,所有患者均进行了广泛性子宫切除＋盆腔淋巴结清扫术,临床分期均为ⅠA2~ⅡA2期,对影响早期宫颈癌宫旁转移的相关危险因素进行单因素分析和多因素分析。结果：890例早期宫颈癌患者中共有53例患者出现宫旁转移,转移率为6.0%（53/890）。单因素分析结果显示,临床分期、肿瘤大小、血清鳞状细胞癌抗原（squamous cell carcinoma antigen,SCC-Ag）水平、肿瘤浸润深度、脉管浸润、手术切缘状态、淋巴结转移、累及宫体和累及阴道是早期宫颈癌宫旁转移的危险因素（P值均〈0.01）。多因素分析发现,肿瘤浸润深度、脉管浸润和淋巴结转移是早期宫颈癌宫旁转移的独立危险因素（P值均〈0.01）。结论：早期宫颈癌患者的宫旁转移率较低,肿瘤浸润深度、脉管浸润和淋巴结转移是早期宫颈癌宫旁转移的独立危险因素。
Objective：To investigate the risk factors of parametrial involvement in early-stage cervical cancer.Methods：Clinical and pathological information of 890 patients with early-stage cervical cancer treated in Tangxia People＇s Hospital of Ruian City between March 2010 and August 2015 were analyzed.All patients underwent extensive hysterectomy and pelvic lymph node dissection and were diagnosed of stage ⅠA2-ⅡA2 cervical cancer.The risk factors of parametrial involvement in early-stage cervical cancer were evaluated by using univariate and multivariate analyses.Results：Of 890 patients,53（6.0%,53/890） had parametrial involvement.The univariate analysis indicated that the clinicalstage,tumor size,serum squamous cell carcinoma antigen（SCC-Ag） level,depth of tumor invasion,vascular invasion,surgical margin status,lymph node metastasis,involvement of uterine body,and involvement of vagina were the risk factors of early-stage cervical cancer（all P 〈0.01）.Multivariate analysis indicated that the depth of tumor invasion,vascular invasion and lymph node metastasis were independent risk factors of early-stage cervical cancer（all P 〈0.01）.Conclusion：The rate of parametrial involvement in early-stage cervical cancer is relatively low.The depth of tumor invasion,vascular invasion and lymph node metastasis are the independent risk factors of parametrial involvement in early-stage cervical cancer.
出处
《肿瘤》
CAS
CSCD
北大核心
2016年第4期466-473,共8页
Tumor
关键词
子宫肿瘤
肿瘤转移
淋巴转移
Uterine neoplasms
Neoplasm metastasis
Lymphatic metastasis
