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幽门螺杆菌感染对消化性溃疡患儿免疫功能的影响 被引量:8

The Influence of Helicobacter Pylori on the Immune Function of Childrenwith Peptic Ulcer
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摘要 目的分析幽门螺杆菌(Hp)感染对消化性溃疡(PU)患儿免疫功能的影响。方法 ELISA法分别检测49例Hp阳性和30例Hp阴性的PU患儿IL-2、IL-4、TNF-α和INF-γ水平;将Hp阳性的PU患儿分为两组,观察组先予PPI、阿莫西林、甲硝唑根治Hp,而对照组先单独运用PPI类药物,比较4种细胞因子的变化。结果治疗前,Hp阳性患儿IL-4水平低于Hp阴性者(P<0.05),INF-γ水平高于Hp阴性者(P<0.05)。观察组根治Hp后复测IL-4水平较根治前有所升高,而INF-γ水平较前下降(P<0.05)。结论 Hp感染可能引起细胞免疫应答失衡,了解IL-4、INF-γ水平对指导Hp根治治疗有一定价值。 Objective To analyze the effect of helicobacter pylori( Hp) on the immune function of children with peptic ulcer( PU). Methods Enzyme- linked immunosorben assay( ELISA) was conducted to detect serum level of IL-2,IL-4,TNF- α and INF- γin in 49 cases of children with UP( the Hp being positive) and 30 cases of PU( the Hp being negative). The former group was divided into two groups: 25 cases of children in observation group took PPI,amoxicillin and metronidazole to eradicate Hp,while 24 cases of children in control group were given PPI alone. The changes of the four kinds of cytokines of both groups were compared afterwards.Results Before treatment,the value of IL- 4 in Hp positive PU children was lower than that of Hp negative PU children,while on the contrary,INF- γ was obviously higher than that of Hp negative children( P〈0. 005). The content of IL- 4 was raised and INF- γwas reduced after treatment aimed at eradicating Hp in the observation group( P〈0. 05). Conclusion Hp infection may cause imbalance in the cellular immune response,and the detection of levels of IL- 4 and INF- γ can help to eradicate Hp.
出处 《辽宁医学院学报》 CAS 2016年第2期58-60,共3页 Journal of Liaoning Medical University (LNMU) Bimonthly
关键词 幽门螺杆菌 消化性溃疡 白介素-4 干扰素-Γ helicobacter pylori peptic ulcer interleukin-4 interferon-γ
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  • 1Liu S, Luo J,Liu Y, et al. CD4(+)Foxp3(+)regula-toiy T - cell number increases in the gastric tissue of C57BL/6 mice infected with Helicobacter pylori [J]. APMIS,2015,123(7):571-579.
  • 2Shiu J, Blanchard TC. Dendritic cell function in the host response to Helicobacter pylori infection of the gastric mucosa [J]. Pathog Dis,2013,67(I);46-53.
  • 3Varedi M, Shiri H, Moattari A, et al. Hyperthyroid state or in vitro thyroxine treatment modulates THl/TH2 responses during exposure to HSV -1 antigens [J]. J Immunotoxicol,2014,11(2);160-165.
  • 4Pafttorelli L, Garg RR, Hoang SB, el al. Epilhelial - derived IL -33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Thl/Th2 driven enteritis [J]. Proc Natl Acad Sci USA,2010,107(17):8017-8022.
  • 5Pang YH, Zheng CQ, Yang XZ, et al, Increased expression and activation of IL -12- induced Stat4 signaling in the mucosa of ulcerative colitis patients [J]. Cell Immunol,2007,248(2):115-120.
  • 6Freire de Melo F,Rooha GA,Rocha AM,et al. Thl immune response to Hpylori infection varies according to the age of the patients and influences the gastric inflammatory patterns [J]. Int J Med Microbiol,2014,304(4):300-306.
  • 7Siregar GA,Halim S,Sitepu VR. Serum TNF - a, IL -8, VEGF Levels in Helicobacter pylori Infection and Their Association with Degree of Gastritis [J]. Acta Med Indones,2015,47(2):120-126.
  • 8李林艳.三联法治疗幽门螺杆菌消化性溃疡患者临床疗效及Th1/Th2细胞因子的变化[J].中国医药导刊,2014,16(11):1393-1394. 被引量:10
  • 9Abdiev S,Ahn KS, Khadjihaev A, et al. Helicobacter pylori infection and cytokine gene polymorphisms in Uzbeks [J]. Nagoya J Med Sci,2010,72(4):167-172.
  • 10杨清峰,江泳,张旭,张爽,周磊,刘伟,张群超.幽门螺杆菌感染者Th1/Th2细胞免疫应答变化[J].中国微生态学杂志,2011,23(10):914-915. 被引量:16

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