摘要
血管支架尤其是药物洗脱支架的使用很大程度上解决了冠状动脉管腔丢失的问题,然而支架术后仍有10%～20%的患者发生支架内再狭窄,药物洗脱支架的晚期血栓发生率亦呈上升趋势,极大地影响着接受支架置入治疗患者的生存率和生活质量。研究显示支架术后再内皮化延迟与支架内再狭窄及晚期血栓的发生密切相关,而内皮覆盖率是重要的预测指标。因此如何促进血管内皮细胞修复及功能改变,成为当今心内科基础和临床领域的研究热点。现从加速再内皮化的药物、内皮祖细胞相关研究以及基因治疗三方面就血管支架再内皮化的研究进展进行综述。
The use of vascular stent, especially durg-eluting stent has dramatically reduced the luminal losing of coronary artery. However, 10%-20% patients caused in-stent restenosis after stenting, late thrombosis rate of drug-eluting stent showed an upward trend, it influenced the survival rate and life quality of patients under carotid angioplasty and stenting. Researches showed that endothelial progenitor cell was closely to in-stent restenosis and late thrombosis, and endothelial cells coverage was a vital predictor of re-endothelial. As a consequence, how to repair endothelial cells and change function becomes the hot issue of cardiology basic and clinical aspects, this article reviews vascular scaffold reendothelialization from 3 aspects of endothelial drugs acceleration, research on endothelial progenitor cell and gene therapy.
出处
《中国医药导报》
CAS
2016年第9期55-58,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81273949)
关键词
药物涂层支架
再内皮化
内皮细胞
内皮祖细胞
基因
Drug-eluting stent
Re-endothelial
Endothelial cells
Endothelial progenitor cells
Gene
