摘要
目的 观察应用胰岛素泵在老年2型糖尿病合并肺部感染患者中的临床疗效。方法 纳入2013年11月~2015年6月在北京军区总医院住院的老年2型糖尿病合并肺部感染患者60例,其中男性42例,女性18例,年龄61~85岁,平均年龄（69.4±6.8）岁。将患者随机分为对照组和治疗组,每组各30例。对照组给予分次皮下注射胰岛素,治疗组应用胰岛素泵持续输注胰岛素。比较治疗前后两组患者的血糖水平,记录胰岛素用量及低血糖发生率。结果 两组治疗第3 d和第15 d各时段血糖水平与治疗前相比均有明显下降,差异有统计学意义（P均〈0.01）。治疗第3 d时,治疗组的各时段血糖水平较对照组改善更明显,分别为空腹血糖[（6.3±1.2）mmol/L vs.（8.6±2.0）mmol/L],早餐后2 h血糖[（8.0±2.0）mmol/L vs.（9.5±2.2）mmol/L],晚餐前0.5 h血糖[（6.2±1.6）mmol/L vs.（8.3±2.1）mmol/L],睡前血糖[（6.9±1.4）mmol/L vs.（9.0±2.0）mmol/L],差异有统计学意义（P均〈0.05）。而治疗第15 d时两组各时段的血糖水平差异无统计学意义（P均〉0.05）。与对照组比较,治疗组的胰岛素用量少,低血糖发生率低,差异有统计学意义（P均〈0.05）。结论 胰岛素泵对老年2型糖尿病合并肺部感染患者的血糖能起到较好的控制作用,且胰岛素用量少,低血糖发生率低。
Objective To observe the clinical efficacy of insulin pump in elderly patients with type 2 diabetes mellitus （T2DM） complicating pulmonary infection. Methods The patients （n=60, male 42, female 18, aged from 61 to 85 and average age=69.4± 6.8） were chosen from Nov. 2013 to Juu. 2015, and then randomly divided into control group and treatment group （each n=30）. The control group was given multiple subcutaneous injection of insulin, and treatment group was given continuous infusion of insulin by using insulin pump. The level of blood glucose was compared, and insulin dosage and incidence of hypoglycemia were recorded in 2 groups before and after treatment. Results The level of blood glucose decreased significantly at different time points in 2 groups after treatment for 3 d and 15 d （all P〈0.01）. After treatment for 3 d, the level of blood glucose decreased more significantly at different time points in treatment group compared with control group （all P〈0.05）： fasting plasma glucose [（6.3± 1.2） mmol/L vs. （8.6 ± 2.0） mmol/L], plasma glucose 2 h after breakfast [（8.0 ± 2.0） mmol/L vs. （9.5± 2.2） mmol/L], plasma glucose 0.5 h before supper [（6.2 ±1.6） mmol/L vs. （8.3 ± 2.1）mmol/L] and plasma glucose before sleeping [（6.9 ± 1.4） mmol/L vs. （9.0 ± 2.0） mmol/L]. After treatment for 15 d, the difference in level of blood glucose had no statistical significance at different time points between 2 groups （all P〉0.05）. Compared with control group, the dosage of insulin was less, and the incidence of hypoglycemia was lower in treatment group （all P〈0.05）. Conclusion Insulin pump can control well the level of plasma glucose with less insulin dosage and lower incidence of hypoglycemia in patients with T2DM complicating pulmonary infection.
出处
《中国循证心血管医学杂志》
2016年第3期339-341,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词
胰岛素泵
肺部感染
老年
糖尿病
2型
Insulin pump
Pulmonary infection
Elderly patients
Type 2 diabetes mellitus
