摘要
本文概述了氨基质子转移(amide proton transfer,APT)技术与化学交换饱和转移(chemical exchange saturation transfer,CEST)技术的关系、APT技术的原理、影响APT技术的诸多因素,特别是在体APT成像需研究核奥氏效应(nuclear Overhauser effect,NOE)的重要性。阐述了APT技术的应用,主要有p H成像、温度成像、APT加权像在各器官组织的临床应用。
Amide proton transfer（APT） imaging is related to chemical exchange saturation transfer（CEST） technique. This review focuses on description of APT technical principles, factors influencing APT imaging, and relationship between in vivo APT imaging and nuclear Overhauser effect（NOE）. Potential clinical applications of APT technique, such as p H imaging, temperature imaging, as well as APT-weighted imaging for organs and tissues, are discussed.
出处
《磁共振成像》
CAS
CSCD
2016年第4期254-258,共5页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金项目(编号:81471730)~~
关键词
氨基质子转移
化学交换饱和转移
核奥氏效应
酸碱度成像
温度成像
Amide proton transfer
Chemical exchange saturation transfer
Nuclear Overhauser effect
p H imaging
Temperature imaging
