摘要
目的:分析甲亢性心衰患者测定血脑利钠肽(BNP)与胱抑素C(Cys-C)水平的临床意义。方法:选择83例甲亢性心衰患者,根据心功能NYHA分级分为:NYHAⅡ级组27例、NYHAⅢ级组31例和NYHAⅣ级组25例,选择同期甲亢患者30例作为对照组,比较各组BNP和Cys-C水平;所有患者均随访6个月,观察高Cys-C水平和低Cys-C水平患者再入院次数、平均住院时间、心血管事件发生情况及死亡情况。结果:甲亢性心衰各组患者FT3,FT4,BNP,Cys-C水平均高于对照组,差异有统计学意义(P<0.05);NYHAⅣ级组患者FT3,FT4水平高于NYHAⅡ级组和NYHAⅢ级组,差异有统计学意义(P<0.05);NYHAⅢ级患者FT3,FT4水平高于NYHAⅡ级组,差异有统计学意义(P<0.05)。随访6个月,高Cys-C水平组患者平均住院时间较低Cys-C水平组长,患者再入院、心血管事件发生率及病死率均高于低Cys-C水平组,差异有统计学意义(P<0.05)。结论:BNP和Cys-C水平与甲亢性心衰患者甲亢轻重程度,心功能NYHA分级呈正相关,可作为评估病情和预后的重要指标。
Objective： To detect hyperthyroid heart failure patients by determination of serum brain natriuretic peptide（ BNP） and cystatin C（ Cys） level,and to analyze its clinical significance. Methods： 83 patients with hyperthyroidism heart failure in our hospital were divided into a NYHA grade II group（ 27 cases）,a NYHA grade III group（ 31 cases） and a NYHA grade IV group（ 25 cases）.30 cases of hyperthyroidism patients were selected as a control group. BNP and Cys-C levels were compared between the groups. All the patients were followed up for 6 months,and the average hospitalization time,cardiovascular events and mortality in the patients with high Cys-C and low Cys-C levels were observed. Results： The levels of FT4 and FT3 in the patients with chronic heart failure were higher than those in the hyperthyroidism group,and the levels of BNP and Cys-C were higher than those in the hyperthyroidism group（ P 0. 05）; the levels of FT4 and FT3 in the NYHA grade IV group were higher than those in the NYHA grade II and grade III groups（ P 0. 05）; the levels of FT4 and FT3 in the NYHA grade III group were higher than those in the NYHA grade II group（ P 0. 05）. After6 months＇ follow-up,the average hospital stay in the patients with high Cys-C level was longer than that of the low Cys-C group,and the incidence of cardiovascular events and mortality were also higher. The difference was statistically significant（ P 0. 05）. Conclusion：The levels of BNP and NYHA were positively correlated with the severity of hyperthyroidism in patients with heart failure,and can be used as an important index for the evaluation of the severity of the disease.
出处
《淮海医药》
CAS
2016年第3期276-278,共3页
Journal of Huaihai Medicine
