摘要
目的分析广东省细菌耐药监测网2014年度细菌分布及耐药情况。方法采用标准纸片扩散法或自动化仪器检测法,测定监测药物对细菌敏感性,用WHONET 5.6软件进行数据分析。结果共有59家医院的171332株细菌药敏试验信息纳入研究,包括革兰阴性菌117538株(68.6%)和革兰阳性菌53794株(31.4%)。耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)检出率为36.7%。万古霉素耐药粪肠球菌和屎肠球菌分别占0.3%和1.8%。青霉素耐药的肺炎链球菌比例为4.8%。革兰阴性菌中分离率前3位分别为大肠埃希菌(30.7%)、克雷伯菌属(16.8%)和铜绿假单胞菌(14.7%)。大肠埃希菌对头孢噻肟的耐药率为53.9%。肺炎克雷伯菌对亚胺培南耐药率为2.4%。铜绿假单胞菌对碳青酶烯类、氨基糖苷类、哌拉西林/三唑巴坦、头孢吡肟和头孢他啶的耐药率低于17.5%。鲍曼不动杆菌对大多数监测药物耐药率超过44.0%。广泛耐药肺炎克雷伯菌(extensively drug-resistant Klebsiella pneumoniae,XDRKP)和鲍曼不动杆菌(extensively drug-resistant Acinetobacter baumannii,XDRAB)比例分别为7.8%和22.1%。结论我省细菌耐药菌的构成比以及对常见抗菌药物耐药性与既往监测比较变化不大,鲍曼不动杆菌的耐药状况仍然最突出。
Objective To explore the bacterial drug resistance and its epidemic tendency in 2014 from the members of Antimicrobial Resistant Investigation Net of Guangdong province. Methods All the objective bacterial isolates were collected and identified by unified protocol, and then analyzed the susceptibility date by software WHONET 5.6 . Results 171,332 bacterial isolates and their antibacterial susceptibility data were collected from all the59 members of Antimicrobial Resistant Investigation Net, which included 117,538 （68.6%） gram-negative bacterial isolates and 53794 （31.4%） gram-positive bacterial isolates. The isolating rates of methicillin-resistant Staphylococcus aureus （MRSA） was 36.7%. There were 0.3% E. faecalis and 1.8% E. faecium resistant to vancomycin. 4.8% penicillin- resistant Streptococcus pneumoniae were found. The top three populations of gram-negative bacterial isolates were E. coli（30.7%）, Klebsiella（16.8%）, P aeruginosa（14.7%）, respectively. There were above 53.9% E. coli resistant to cefotaxime. 2.4% Klebsiella pneumoniae were resistant to imipenem. The resistant rate of P. aeruginosa to carbapenems, aminoglycosides, piperacillin/tazobactam, cefepime and ceftazidime were under 17.5%. The resistance rates of A.baumannii to most surveillance drugs including carbapenem were above 44.0%. The percentage of extensively drug-resistant Klebsiella pneumoniae （XDRKP） and extensively drug-resistant Acinetobacter baumannii （XDRAB）were 7.8% and 22.1%, respectively. Conclusion Compared with the previous, the constituent ratio of drug-resistance bacteria and the resistance to the common antibiotics have little change. The drug resistance situation ofA. baumanni was still outstanding.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2016年第4期289-295,共7页
Chinese Journal of Antibiotics
关键词
细菌耐药性监测
耐药率
细菌感染
Bacterial resistance surveillance
Resistance rate
Bacterial infection
