摘要
目的研究特发性中枢性性早熟（ICPP）女童干预治疗对体质量指数（BMI）的影响。方法对156例ICPP女童进行长期随访研究，其中106例予促性腺激素释放激素类似物（GnRHa）治疗，疗程为（25．30±1．43）个月，测量治疗前、治疗结束时及近成年身高时的身高、体质量，计算BMI，并与50例未治疗的患儿（对照组）进行比较。采用t检验分析2组间的差异。结果1．治疗组在治疗前、治疗结束时及近成年身高时的年龄标准差分值（BMISDS）都处于正常范围内，其中治疗前及治疗结束时的年龄BMISDS接近，近成年身高时年龄BMISDS略有降低，但差异均无统计学意义（P均〉0．05），对照组在治疗前及近成年身高时的年龄BMIS—DS前后比较及与治疗组比较差异均无统计学意义（P均〉0．05）。2．治疗组在治疗前、治疗结束时和近成年身高时超重比例分别为18．8％、15．0％、9．4％，肥胖比例分别为8．4％、6．6％、4．7％，对照组在治疗前和近成年身高时超重比例分别为14．0％、6．0％，肥胖比例分别为8．0％、4．0％，2组前后比较和两两比较差异均无统计学意义（P均〉0．05）。3．2组显示近成年身高时年龄BMISDS与治疗前均呈正相关（r=0．708、0．671，P均〈0．01）。结论GnRHa治疗对BMI没有影响，无明显导致肥胖的倾向，少数患儿出现的肥胖与其初始BMI有关。
Objective To study the impact of intervention treatment on body mass index（BMI） in girls with idiopathic central precocious puberty （ICPP）. Methods One hundred and fifty - six cases girls with ICPP had a long -term follow -up study, and 106 out of the 156 girls were treated with gonadotropin - releasing hormone analogs （GnRHa） for （25.30 ± 1.43 ） months. And their height,weight, and BMI were measured before treatment, at the end of the treatment and after reaching near adult height, which was compared with those in the untreated 50 girls （control group）, and t test was used to analyze the differences between the 2 groups. Results （ 1 ） The age BMI standard devia- tion score （BMISDS） in the GnRHa treatment group before treatment, at the end of the treatment and after reaching near adult height remained in the normal range;among them, the age BMISDS before treatment was similar to that at the end of the treatment, and was slightly higher than that after reaching near adult height, but there was no significant difference （ all P 〉 0.05 ） ; in the control group, the age BMISDS before treatment was similar to that after reaching near adult height, compared with the treatment group the difference was not significant （ all P 〉 0. 05 ）. （ 2 ） In the GnRHa treat- ment group, the proportion of overweight before treatment, at the end of the treatment and after reaching near adult height,was 18.8%, 15.0% ,9.4% ,and obesity was 8.4% ,6.6% ,4.7% ,in the control group,the proportion of over- weight before treatment and after reaching near adult height was 14.0% ,6.0% ,and obesity was 8.0% ,4.0% ,there was no significant difference between 2 groups and by tournament method before and after treatment （ all P 〉 0.05 ）. （3） The age BMISDS in 2 groups showed a positive correlation between after reaching near adult height and before treatment （ r = 0. 708,0.671, all P 〈 0.01 ）. Conclusions GnRHa treatment has no effect on BMI, no obvious tendency to leading to obesity, and a few children with obesity are related to its initial BMI.
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2016年第8期592-595,共4页
Chinese Journal of Applied Clinical Pediatrics
