摘要
目的探讨盐酸美金刚改善帕金森病痴呆患者认知功能及日常生活能力的效果。方法选取本院2013年9月-2015年9月收治的69例帕金森病痴呆患者作为研究对象,随机分为对照组（n=34）与观察组（n=35）。对照组给予盐酸多奈哌齐治疗,观察组给予盐酸美金刚治疗。比较两组的认知功能、日常生活能力及药物不良反应发生率。结果观察组治疗后8、16周的Mo CA评分及MMSE评分显著高于对照组,差异有统计学意义（P〈0.05）。观察组的日常生活能力优良率为80.0%,显著高于对照组的55.9%,差异有统计学意义（P〈0.05）。观察组的不良反应发生率显著低于对照组,差异有统计学意义（P〈0.05）。结论盐酸美金刚治疗帕金森病痴呆具有较好的临床效果,能够有效改善患者的认知水平及生活能力,不良反应发生率低,值得临床推广应用。
Onjective To explore the effect of memantine hydrochloride in improving cognitive function and ability of daily life of Parkinson disease patients with dementia. Methods 69 Parkinson disease patients with dementia from September 2013 to September 2015 in our hospital were selected and randomly divided into the control group（n=34）and the observation group（n=35）.The control group was treated with donepezil hydrochloride,the observation group was treated with memantine hydrochloride.The cognitive function,ability of daily life and the incidence rate of adverse reaction in the two groups was compared. Results The score of Mo CA and MMSE after treatment for 8 and 16 weeks in the observation group was higher than that in the control group,with significant difference（P〈0.05）.The excellent and good rate of ability of daily life in the observation group was 80.0%,which was higher than 55.9% in the control group,with significant difference（P〈0.05）.The incidence rate of adverse reaction in the observation group was lower than that in the control group,with significant difference（P〈0.05）. Conclusion Memantine hydrochloride in the treatment of Parkinson disease and dementia has good clinical effect,which can obviously improve the cognitive function and ability of daily life of patients,and the incidence rate of adverse reaction is low,it is worthy of clinical promotion and application.
出处
《中国当代医药》
2016年第9期97-99,共3页
China Modern Medicine
关键词
盐酸美金刚
帕金森病
痴呆
认知
日常生活能力
Memantine hydrochloride
Parkinson disease
Dementia
Cognition
Ability of daily life
