期刊文献+

氯吡格雷联合阿司匹林对基底动脉闭塞早期卒中再发的预防效果观察 被引量:2

下载PDF
导出
摘要 目的评价氯吡格雷联合阿司匹林对基底动脉闭塞早期卒中再发的预防效果。方法选取2009年8月至2015年4月中国人民解放军第一五四中心医院收治的61例轻症基底动脉闭塞患者,均经CTA检查证实基底动脉闭塞且存在病变血管相关的缺血性卒中。所有患者均在缺血性事件发生24 h内给予抗血小板治疗,根据抗栓治疗方案不同分为双抗组(氯吡格雷联合阿司匹林,33例)和单抗组(阿司匹林,28例)。结果双抗组和单抗组30 d内卒中复发率分别为15.2%(5/33)和39.3%(11/28);双抗组30 d内卒中复发率低于单抗组,差异有统计学意义(P<0.05)。双抗组和单抗组致死致残性卒中率分别为9.1%(3/33)和32.1%(9/28);双抗组致死致残性卒中率低于阿司匹林组(P<0.05)。结论基底动脉闭塞早期卒中复发率高,氯吡格雷联合阿司匹林治疗效果优于阿司匹林单抗血小板治疗。
出处 《河南医学研究》 CAS 2016年第3期431-433,共3页 Henan Medical Research
  • 相关文献

参考文献15

  • 1Strbian D,Sairanen T,Silvennoinen H,et al.Thrombolysis of basilar artery occlusion:impact of baseline ischemia and time[J].Ann Neurol,2013,73(6):688-694.
  • 2Schonewille W J,Wijman C A,Michel P,et al.Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study(BASICS):a prospective registry study[J].Lancet Neurol,2009,8(8):724-730.
  • 3Caplan L R.Occlusion of the vertebral or basilar artery:Follow up analysis of some patients with benign outcome[J].Stroke,1979,10(3):277-282.
  • 4Lindsberg P J,Soinne L,Tatlisumak T,et al.Long-term outcome after intravenous thrombolysis of basilar artery occlusion[J].JAMA,2004,292(15):1862-1866.
  • 5Chimowitz M I,Lynn M J,Howlett-Smith H,et al.Comparisen of warfarin and aspirin for symptomatic intracranial arterial stenosis[J].N Engl J Med,2005,352(13):1305-1316.
  • 6Wang Y,Wang Y,Zhao X,et al.Clopidogrel with aspirin in acute minor stroke or transient ischemic attack[J].N Engl J Med,2013,369(1):11-19.
  • 7Wong K S,Huang Y N,Gao S,et al.Intracranial stenosis in Chinese patients with acute stroke[J].Neurology,1998,50(3):812-813.
  • 8Lindsberg P J,Soinne L,Roine R O,et al.Options for recanalization therapy in basilar artery occlusion[J].Stroke,2005,36(2):203-204.
  • 9Kasner S E,Chimowitz M I,Lynn M J,et al.Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis[J].Circulation,2006,113(4):555-563.
  • 10Gao S,Wang Y J,Xu A D,et al.Chinese ischemic stroke subclassification[J].Front Neurol,2011,2:6.

二级参考文献33

  • 1Sidler D, Renz N, Brekenfeld C, et al. Basilar artery occlusion after acute myocardial infarction. Int J Cardiol, 2012, 155: 293 -294.
  • 2Schonewille WJ, Wijman CA, Michel P, et al. Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS) : a prospective registry study. Lancet Neurol,2009,8:724-730.
  • 3Lindsberg PJ, Soinne L, Tatlisumak T, et al. Long-term outcome after intravenous thrombolysis of basilar artery occlusion. JAMA, 2004,292 : 1862-1866.
  • 4Rha JH, Saver JL The impact of recanalization on ischemic stroke outcome : a meta-analysis. Stroke,2007,38:967-973.
  • 5Dashti SR, Park MS, Stiefel MF, et al. Endovascular recanalization of the subacute to chronically occluded basilar artery : initial experience and technical considerations. Neurosurgery, 2010,66 : 825 -831.
  • 6Lin R, Aleu A, Jankowitz B, et al. Endovascular revascularization of chronic symptomatic vertebrobasilar occlusion. J Neuroimaging ,2012,22:74-79.
  • 7Chimowitz MI, Lynn MJ, Derdeyn CP, et al. Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med,2011,365 :993-1003.
  • 8Higashida RT, Furlan A J, Roberts H, et al. Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke. Stroke,2003,34 : e109-e137.
  • 9de Haan R, Limburg M, Bossuyt P, et al. The clinical meaning of Rankin handicap grades after stroke. Stroke, 1995, 26: 2027 -2030.
  • 10Samuels OB, Joseph GJ, Lynn MJ, et al. A standardized method for measuring intracranial arterial stenosis. AJNR, 2000, 21: 643 -646.

共引文献16

同被引文献19

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部