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辅助性T细胞22／白细胞介素-22在类风湿关节炎中的研究进展 被引量：5

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摘要 RA是慢性炎症性自身免疫病，临床表现以滑膜炎症和进行性关节破坏为特征，病理特征表现为免疫细胞侵润和滑膜成纤维细胞增生导致骨和关节的破坏。该病的病因和发病机制尚不明确，目前共识其发生和发展是一个免疫介导事件。CD4＋T细胞活化和分化，介导免疫应答，刺激B细胞产生抗体，产生细胞因子发生级联反应活化滑膜、骨、软骨细胞产生效应分子，引起以组织破坏为主要特征的慢性炎症。
作者 邵勤 吴斌
机构地区 重庆市中医院风湿病科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2016年第4期274-278,共5页 Chinese Journal of Rheumatology
基金 重庆市卫计委医学科研项目（2015MSXM080）
关键词 类风湿关节炎 白细胞介素 辅助性T细胞 慢性炎症性自身免疫病 成纤维细胞增生 T细胞活化 滑膜炎症 软骨细胞
分类号 R593.22 [医药卫生—内科学]
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参考文献46

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二级参考文献63

  • 1陈捷,王兰兰,冯伟华,蔡蓓,曾婷婷.共刺激分子CD28CD152在类风湿关节炎患者T细胞亚群上表达异常的研究[J].中华风湿病学杂志,2004,8(11):674-677. 被引量：4
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共引文献28

同被引文献88

引证文献5

二级引证文献48

中华风湿病学杂志
2016年 第4期

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