期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

乳腺癌组织中Yes相关蛋白的表达及其与肿瘤侵袭转移的关系 被引量：6

Expression of Yes - associated protein in breast cancer tissue and the relationship with breast cancer invasion and metastasis
原文传递
导出
摘要 目的观察Yes相关蛋白（YAP）在乳腺癌及癌旁组织中的表达情况，探讨其与乳腺癌侵袭转移的关系。方法收集我院2008年1月至2009年1月手术治疗的乳腺癌患者资料以及石蜡标本共177例。采用免疫组织化学的方法观察YAP、基质金属蛋白酶（MMP）-2在乳腺癌组织及癌旁组织的表达情况，探讨YAP与乳腺癌侵袭转移的关系。结果（1）YAP在乳腺癌组织中的表达率仅为29．8％（28／94），显著低于YAP在癌旁组织中的表达率（74．7％，62／83），差异有统计学意义；发现YAP的低表达与组织学类型（x^2=20．897，P〈0．01）和肿块的大小（x^2=6．623，P〈0．05）有关；YAP在乳腺癌组织内的表达主在胞质，而在正常乳腺上皮组织中的表达主在细胞核内。（2）乳腺癌组织中YAP与MMP-2的表达呈负相关（r=-0．253，P〈0．05）。YAP的低表达与组织学类型肿块大小有关，MMP-2的高表达与淋巴结是否发生转移有关。结论YAP在乳腺癌组织可能扮演抑癌基因的角色，其可能抑制肿瘤的侵袭转移。 Objective To observe the expression of Yes - associated protein （YAP） in breast cancer tissues and adjacent tissues. To explore the relationship between YAP and breast cancer invasion and metastasis. Methods Collected the surgical treatment of breast cancer patients＇ clinical data and par- affin specimens from January 2008 to January 2009 in our hospital. The results showed that we collected a total of 177 cases, with 94 cases of breast cancer tissue and 83 cases adjacent to carcinoma. Through im- munohistochemical methods and explore the relationship between YAP and Breast Cancer invasion and me- tastasis. Results （ 1 ） The expression rates of YAP in breast cancer tissues is 29. 8% （28/94） which is significantly lower than that of in adjacent tissues to carcinoma （74. 7%, 62/83 ） and the difference has statistically significant. In breast cancer tissues, YAP protein is mainly located in the cytoplasm, while in normal breast epithelium, YAP protein is mainly located nucleus. The lack or low of YAP in breast cancer tissues is correlation with histological type （x^2 = 20. 897, P 〈 0. 01 ） and tumor size （x^2 = 6. 623, P 〈 0. 05 ）. （ 2 ） YAP expression has negatively correlated with the expression of matrix metalloproteinase - 2 （ MMP - 2, r = - 0. 253, P 〈 0. 05 ）. Conclusion YAP functions as a tumor suppressor gene in breast cancer, which may suppress tumor invasion and metastasis.
作者 梁明 张亦磊 范志刚 肖栋 相建国 刘晓晨 王健生
机构地区 西安交通大学医学院附属 西安交通大学第一附属医院肿瘤外科
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2016年第4期914-916,共3页 Chinese Journal of Experimental Surgery
关键词 乳腺癌 Yes相关蛋白 基质金属蛋白酶-2 相关性 Breast cancer Yes - associated protein Matrix metalloproteinase - 2 Correla- tion
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献10

  • 1Steinhardt AA, Gayyed MF, Klein AP, et al. Expression of Yes-associ- ated protein in common solid tumors [ J ]. Hum Pathol, 2008,39 ( 11 ) : 1582-1589. DOI:10. 1016/j. humpath. 2008.04. 012.
  • 2Yuan M, Tomlinson V, Lara R, et al. Yes-associated protein (YAP) functions as a tumor suppressor in breast [ J ]. Cell Death Differ, 2008,15 ( 11 ) : 1752-1759. DOI:10. 1038/cdd. 2008. 108.
  • 3Ehsanian R, Brown M, Lu H, et al. YAP dysregulation by phosphoryl- ation or DeltaNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets [ J ]. Onco- gene,2010,29(46) :6160-6171. DOI : 10. 1038/onc. 2010. 339.
  • 4Li WP, Anderson CJ. Imaging matrix metalloproteinase expression in tumors[J]. Q J Nucl Med ,2003,47 ( 3 ) :201-208.
  • 5Sudol M. Yes-associated protein ( YAP65 ) is a proline-rieh phospho- protein that binds to the SH3 domain of the Yes proto-oneogene prod- uct [ J ]. Oncogene, 1994,9 ( 8 ) :2145-2152.
  • 6Wang H,Du YC ,Zhou XJ,et al. The dual functions of YAP-I to pro- mote and inhibit cell growth in human malignancy [ J ]. Cancer Metas- tasis Rev,2013,33 ( 1 ) : 173-181. DOI : 10. 1007/s10555-013-9463-3.
  • 7Cai H, Xu Y. The role of LPA and YAP signaling in long-term migra- tion of human ovarian cance cells [ J ]. Cell Commun Signal ,2013,11 ( 13 ) : 1562-1575. DOI:10.1186/1478-811X-11-31.
  • 8Strano S, Munarriz E, Rossi M, et al. Physical interaction with Yes-as- sociated protein enhances p73 transcriptional activity [ J ]. J Biol Chem,2001,276- (18) :15164-15173. DOI:10. 1074/jbc. M010484200.
  • 9Fan HX, Li HX, Chen D, et al. Changes in the expression of MMP2, MMP9 ,and CollV in stromal cells in oral squamous tongue cell carci- noma:relationships and prognostic implications [ J ]. J Exp Clin Canc- er Res,2012,29 (31) :1652-1658. DOI : 10.1186/1756-9966-31-90.
  • 10Chakraborti S, Mandal M, Das S, et al. Regulation of matrix metallo- proteinases : an overview [ J ]. Mol Cell Biochem, 2003,253 ( 1-2 ) : 269 -285.

同被引文献46

引证文献6

二级引证文献19

中华实验外科杂志
2016年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部