摘要
目的探讨Fascin和c-Met在乳腺癌组织中的表达水平及两者与其临床病理因素的关系。方法收集95例乳腺癌患者手术切除的癌组织和癌旁组织标本，采用免疫组织化学法检测以上组织石蜡切片中Fascin和c—Met的表达水平。结果Fascin在乳腺癌组织中阳性表达率为44．21％，在癌旁组织中阳性表达率为10．53％，两者差异有统计学意义（P〈0．01），Fascin表达水平与乳腺癌乳腺癌组织学分级、TNM分期、淋巴结转移明显相关（P〈0．05）；c-Met在乳腺癌组织中阳性表达率为55．79％，在癌旁组织中阳性表达率为8．42％，两者差异有统计学意义（P〈0．01），c-Met表达水平与乳腺癌肿瘤大小、TNM分期、淋巴结转移明显相关（P〈0．05）。结论检测Fascin及c-Met的表达可能有助于判断乳腺癌的恶性程度及侵袭能力。
Objective To explore the relationship between Fascin, c - Met and elinicopathologic characteristics of breast carcinoma. Methods The expression of Fascin and c - Met was examined in 95 cases of human breast carcinoma tissues and non - cancerous adjacent breast tissues using immunohisto- chemical method. Results The expression rate of Fascin was 44. 21% in breast carcinoma tissues, and 10. 53% in non - cancerous adjacent breast tissues （ P 〈 0. O1 ）. The expression of Fascin was related breast carcinoma to histology grade, TNM stage and lymph node metastasis （ P 〈 0. 05 ）. The expression rate of c- Met was 55.79% in breast carcinoma tissues, and 8.42% in non -cancerous adjacent breast tissues （P 〈 0. 01 ）, and there was a close relation between the expression of c - Met and tumor size, TNM stage and lymph node metastasis （P 〈 0. 05 ）. Conclusion The expression of Fascin and c - Met may help to judge the abilities t of malignancy and invasion of breast carcinoma.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2016年第4期945-946,共2页
Chinese Journal of Experimental Surgery
