摘要
目的探讨麦冬地芍汤治疗干燥综合征的理论依据。方法从中医经典、生理学等方面归纳"肺肠合治法"的科学内涵;分析多篇近年来的国内外文献,总结得出血管活性肠肽与干燥综合征相关。结果宣肺、润肠中药汤剂能够调节模型小鼠肺、肠及颌下腺组织中血管活性肠肽的含量;麦冬地芍汤临床上能有效缓解干燥综合征患者的口干、眼干等症状。结论基于"肺肠合治法"的麦冬地芍汤改善干燥综合征患者的症状可能与上调干燥综合征患者外分泌腺体中血管活性肠肽的表达有关,往后将做进一步的实验研究。
Objective To explore the theoretical basis of treating Sjgren＇s syndrome（ SS） by Maidongdishao Decoction. Methods Sum up the scientific connotation of ＂combination of diffusing lung and lubricating intestine＂from classical works of traditional Chinese medicine and physiology. To come to a conclusion that vasoactive intestinal peptide（ VIP） is related to SS by analysing medical literatures in recent years at home and abroad. Results It has proved that diffusing Lung and lubricating Intestine could upregulated the express of VIP in the intestinal tissue,the lung tissue and the submandibular glands of model mice; Maidongdishao decotion can effectively relieve sjogren＇s syndrome in patients with clinical symptoms such as dry mouth and dry eye. Conclusion The mechanism of Maidongdishao decoction that based on ＂combination of diffusing lung and lubricating intestine＂treating SS maybe related to it can up-regute the VIP expression,which will be done in the further study.
出处
《吉林中医药》
2016年第4期430-432,共3页
Jilin Journal of Chinese Medicine
基金
国家自然科学基金面上项目"基于神经肽VIP研究‘肺肠合治法’治疗干燥综合征的机制"(81473607)
关键词
干燥综合征
麦冬地芍汤
肺肠合治法
血管活性肠肽
Sjgren＇s syndrome
Maidongdishao decoction
combination of diffusing lung and lubricating intestine
vasoactive intestinal peptide（VIP）
